离体灌注大鼠肾脏对含甘氨酸和羟脯氨酸肽的代谢
Metabolism of glycine- and hydroxyproline-containing peptides by the isolated perfused rat kidney.
作者信息
Lowry M, Hall D E, Brosnan J T
出版信息
Biochem J. 1985 Jul 15;229(2):545-9. doi: 10.1042/bj2290545.
Abstract
Isolated perfused rat kidneys removed considerable quantities of glycyltyrosine, glycylhydroxyproline, tetraglycine and prolylhydroxyproline from the perfusate. The component amino acids are released into the perfusate and, in the case of the glycine-containing peptides, there is increased synthesis of serine. Removal of peptides was more than could be accounted for on the basis of filtration, so antiluminal metabolism is indicated. Metabolism of such peptides by the kidney may contribute to renal serine synthesis in vivo.
摘要
离体灌注的大鼠肾脏从灌注液中去除了大量的甘氨酰酪氨酸、甘氨酰羟脯氨酸、四甘氨酸和脯氨酰羟脯氨酸。组成氨基酸被释放到灌注液中，就含甘氨酸的肽而言，丝氨酸的合成增加。肽的去除量超过了基于滤过所能解释的量，因此表明存在管腔外代谢。肾脏对这类肽的代谢可能有助于体内肾脏丝氨酸的合成。
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