Li ZeHui, Wang XiaoXin, Du HuaYong, Liu WuBo, Zhang ChunJia, Talifu Zuliyaer, Xu Xin, Pan Yunzhu, Zhang JinMing, Ke Han, Yang DeGang, Gao Feng, Yu Yan, Jing YingLi, Li JianJun
School of Rehabilitation, Capital Medical University, Beijing, People's Republic of China; Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, People's Republic of China.
School of Rehabilitation, Capital Medical University, Beijing, People's Republic of China; Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, People's Republic of China; Department of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, People's Republic of China.
Adv Nutr. 2025 May 16;16(7):100448. doi: 10.1016/j.advnut.2025.100448.
Spinal cord injury (SCI) leads to severe neurological dysfunction with significant nutritional alterations. These alterations are closely associated with gut dysbiosis and neurogenic gut dysfunction after SCI, creating complex interactions that further exacerbate metabolic disturbances and impede neurological recovery. In the context of SCI, diet not only fulfills basic nutritional needs but also serves as an important therapeutic tool to modulate these interactions. This review provides a broad overview of existing research findings, analyzes the impact of existing dietary interventions on SCI, and attempts to clarify the complex relationship between diet and host and gut microbiota. We hope to provide a clear direction for future research and a scientific basis for the development of personalized dietary interventions to improve the nutritional status of patients with SCI, reduce the incidence of complications such as metabolic disorders, and promote the recovery of neurological function and overall quality of life of patients with SCI.
脊髓损伤（SCI）会导致严重的神经功能障碍，并伴有显著的营养改变。这些改变与SCI后的肠道菌群失调和神经源性肠道功能障碍密切相关，形成复杂的相互作用，进一步加剧代谢紊乱并阻碍神经恢复。在SCI的背景下，饮食不仅满足基本营养需求，还作为调节这些相互作用的重要治疗工具。本综述全面概述了现有研究结果，分析了现有饮食干预对SCI的影响，并试图阐明饮食与宿主及肠道微生物群之间的复杂关系。我们希望为未来的研究提供明确方向，并为制定个性化饮食干预措施提供科学依据，以改善SCI患者的营养状况，降低代谢紊乱等并发症的发生率，促进SCI患者神经功能的恢复和整体生活质量的提高。
