Melamed L B, Selim M A, Schuchman D
Cancer. 1985 Jan 1;55(1):41-3. doi: 10.1002/1097-0142(19850101)55:1<41::aid-cncr2820550106>3.0.co;2-n.
The ototoxicity associated with long-term cisplatin therapy in gynecologic cancer patients was investigated. Twenty-three of 31 patients developed hearing loss and 21 patients reported the onset of tinnitus. The hearing loss was bilateral, cochlear, and permanent. The tinnitus was transient and not predictive of change in hearing level. The likelihood of developing hearing loss appeared to be greatest in patients older than 40 years and in patients with preexisting hearing loss. The amount of change did not appear to be related to the degree of preexisting hearing loss.
对妇科癌症患者长期使用顺铂治疗的耳毒性进行了研究。31例患者中有23例出现听力损失，21例患者报告出现耳鸣。听力损失为双侧、耳蜗性且为永久性。耳鸣是短暂的，且不能预测听力水平的变化。40岁以上患者和已有听力损失的患者发生听力损失的可能性似乎最大。听力变化的程度似乎与已有听力损失的程度无关。
