Fujii Y, Monden Y, Hashimoto J, Nakahara K, Kawashima Y
Clin Immunol Immunopathol. 1985 Jan;34(1):141-6. doi: 10.1016/0090-1229(85)90018-2.
Eleven patients with myasthenia gravis (5 with thymoma) were studied and spontaneous production of antibody to acetylcholine receptor (AChR) in vitro was found by thymus cells in 10 (and in all 5 with thymoma) and by lymph node cells in 8 (and in 3 with thymoma). The rate of AChR antibody production by thymus cells was greater than that by lymph node cells (10.7 +/- 11.6 and 1.4 +/- 1.5 fmol/10(6) cells/week, respectively, mean +/- SD, P less than 0.05 by paired t test), although the B-cell population was always smaller in the thymus than in the lymph nodes (9.5 +/- 9.4 and 31 +/- 12.7%, P less than 0.001), suggesting the principal role of the thymus in AChR antibody production. It is suggested that lymph nodes can be one of the main sites of AChR antibody production in myasthenia gravis but the antibody-producing cells may originate in the thymus.
对11例重症肌无力患者（5例伴有胸腺瘤）进行了研究，发现胸腺细胞在体外可使10例患者（所有5例伴有胸腺瘤的患者均如此）自发产生抗乙酰胆碱受体（AChR）抗体，淋巴结细胞可使8例患者（3例伴有胸腺瘤的患者）产生该抗体。胸腺细胞产生AChR抗体的速率高于淋巴结细胞（分别为10.7±11.6和1.4±1.5 fmol/10⁶细胞/周，均值±标准差，配对t检验P<0.05），尽管胸腺中的B细胞群体总是比淋巴结中的小（分别为9.5±9.4%和31±12.7%，P<0.001），这表明胸腺在AChR抗体产生中起主要作用。提示淋巴结可能是重症肌无力中AChR抗体产生的主要部位之一，但产生抗体的细胞可能起源于胸腺。
