Sefczek D M, Sharma P, Isaacs G H, Brodmerkel G J, Adatepe M H, Powell O M, Nichols K
J Nucl Med. 1985 Jan;26(1):51-3.
A case of gallbladder perforation is presented in which a small bile leak was demonstrated by cholescintigraphy while the patient was receiving meperidine, but not after meperidine was discontinued. The scintigrams obtained during meperidine therapy also showed a pattern of bile-duct obstruction. It is suggested that increased biliary pressure secondary to meperidine administration permitted visualization of the leak. Use of narcotic drugs may be a useful pharmacologic intervention in cases of peritonitis due to small or obscure bile leaks.
本文报告一例胆囊穿孔病例，患者在接受哌替啶治疗时，通过胆闪烁显像显示有少量胆汁漏出，但停用哌替啶后则未显示。在哌替啶治疗期间获得的闪烁扫描图还显示出胆管梗阻的模式。提示哌替啶给药继发的胆道压力升高使得胆汁漏得以显影。在因小的或隐匿性胆汁漏导致的腹膜炎病例中，使用麻醉药物可能是一种有用的药物干预措施。
