Rebec G V, Centore J M, White L K, Alloway K D
Science. 1985 Jan 25;227(4685):438-40. doi: 10.1126/science.4038426.
Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.
氟哌啶醇是一种广泛使用的抗精神病药物，研究人员测试了它阻断大鼠对苯丙胺行为反应的能力，以及在给予生理盐水或抗坏血酸（每千克体重1000毫克）的大鼠中引发僵住症的能力。抗坏血酸本身未能产生显著的行为影响，但它增强了氟哌啶醇（每千克0.1或0.5毫克）的抗苯丙胺和致僵住症作用。这些结果，再加上越来越多的生化证据，表明抗坏血酸在调节氟哌啶醇及相关抗精神病药物的行为影响方面发挥着重要作用。
