Lynch S R, Dassenko S A, Morck T A, Beard J L, Cook J D
Am J Clin Nutr. 1985 Jan;41(1):13-20. doi: 10.1093/ajcn/41.1.13.
Dual radioiron tags were used to measure both heme and nonheme iron absorption simultaneously from meat-containing meals in 76 healthy male volunteers. Partial substitution of beef with soy flour reduced the availability of nonheme iron but improved the percentage absorption of heme iron significantly (27 to 59% rise). In contradistinction three other powerful inhibitors of nonheme iron absorption, bran, tea, and desferrioxamine, had no appreciable effect on heme. Ascorbic acid (100 mg and 1000 mg in separate experiments) improved nonheme iron uptake markedly but also failed to alter the assimilation of heme. These studies demonstrate that the deleterious effects on iron nutrition of substituting soy protein for beef are partially offset by improved availability of the remaining heme iron as well as by an increase in the nonheme iron content of the meal.
采用双放射性铁标记物，对76名健康男性志愿者从含肉餐中同时吸收血红素铁和非血红素铁的情况进行了测定。用大豆粉部分替代牛肉，可降低非血红素铁的利用率，但能显著提高血红素铁的吸收百分比（提高27%至59%）。相反，其他三种非血红素铁吸收的强力抑制剂——麸皮、茶和去铁胺，对血红素铁没有明显影响。在单独实验中，分别使用100毫克和1000毫克的抗坏血酸可显著提高非血红素铁的摄取量，但也未能改变血红素铁的同化作用。这些研究表明，用大豆蛋白替代牛肉对铁营养的有害影响，部分被剩余血红素铁利用率的提高以及餐中非血红素铁含量的增加所抵消。
