Suzuki S, Nakano K
Am J Physiol. 1985 Jan;248(1 Pt 1):E26-30. doi: 10.1152/ajpendo.1985.248.1.E26.
Corticosterone (CS) secretion is stimulated in rats by an intraperitoneal injection of bacterial lipopolysaccharide (LPS) or by subjecting the animals to immobilization stress. LPS injection caused a significant increase in the lung histamine level and a sharp reduction in the number of intact peritoneal mast cells. Injection of compound 48/80, a histamine liberator, provoked an increase in the histamine levels of the blood and lung and a decrease in the number of intact peritoneal mast cells with a concomitant increase in CS secretion. Administration of histamine, at a dose of 10 mg/kg, induced a marked increase in CS release. LPS-induced CS secretion was attenuated by pretreatment with an H1-antihistamine, promethazine (PMZ), whereas an H2-antihistamine, metiamide, had no effect. In contrast, PMZ was ineffective on CS release provoked by immobilization stress. These results suggest that LPS-induced CS release is mediated, in part, by histamine released in the peripheral tissues, whereas an immobilization stress-induced increase is not mediated by the amine.
腹腔注射细菌脂多糖（LPS）或使大鼠遭受固定应激可刺激其皮质酮（CS）分泌。注射LPS会导致肺组胺水平显著升高，完整腹膜肥大细胞数量急剧减少。注射组胺释放剂化合物48/80会引发血液和肺中组胺水平升高，完整腹膜肥大细胞数量减少，同时CS分泌增加。以10 mg/kg的剂量给予组胺会导致CS释放显著增加。用H1抗组胺药异丙嗪（PMZ）预处理可减弱LPS诱导的CS分泌，而H2抗组胺药甲硫米特则无作用。相反，PMZ对固定应激引发的CS释放无效。这些结果表明，LPS诱导的CS释放部分由外周组织释放的组胺介导，而固定应激诱导的增加则不由胺类介导。
