Emu Yixin, Shen Quanli, Yao Qiong, Cai Guanke, Chen Zhuo, Hu Junpu, Hu Chenxi, Hu Xihong
National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Department of Radiology, Children's Hospital of Fudan University, Shanghai, China.
Quant Imaging Med Surg. 2025 May 1;15(5):4720-4733. doi: 10.21037/qims-24-1933. Epub 2025 Apr 28.
Dark-blood T2-weighted fast spin-echo (DB-FSE) is sensitive to motion, leading to signal dropout artifacts and ghosting artifacts in free-breathing pediatric cardiac imaging, which severely impairs its diagnostic quality. Here, we aimed to fulfill high-resolution motion-robust edema assessment during free-breathing by combining reverse double inversion recovery (RDIR) and single-shot DB-FSE based on artificial intelligence (AI)-assisted compressed sensing (ACS) reconstruction.
This prospective study included 20 healthy children and 47 pediatric patients. Three imaging techniques were compared: routine multi-shot DB-FSE based on double inversion recovery (MS-DIR), multi-shot DB-FSE based on RDIR (MS-RDIR), and single-shot DB-FSE based on RDIR (SS-RDIR) with ACS reconstruction. These methods were compared via quantitative metrics, including total acquisition time, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR), and qualitative metrics, including myocardial visibility, ghosting artifacts, and overall quality.
In healthy children, the total acquisition time (seconds) of SS-RDIR (64.8±21.8) was significantly less than those of MS-DIR (222.5±69.3, P<0.001) and MS-RDIR (234.0±64.1, P<0.001). The SNR and CNR were comparable (P=0.094 for SNR and P=0.054 for CNR). Ghosting artifacts were significantly reduced in SS-RDIR (4.70±0.18) compared to MS-DIR (3.95±0.28, P<0.001) and MS-RDIR (3.97±0.31, P<0.001), whereas overall quality was improved in SS-RDIR (4.42±0.19) compared to MS-DIR (3.87±0.27, P=0.004) and MS-RDIR (3.95±0.34, P=0.010). In patients, SS-RDIR significantly reduced the total acquisition time compared to MS-DIR (62.1±24.0 216.6±74.2, P<0.001) and MS-RDIR (229.8±79.2, P<0.001), with comparable SNR (P=0.065) and CNR (P=0.089). SS-RDIR also showed less severe ghosting artifacts (4.94±0.11) compared to MS-DIR (3.77±0.29, P<0.001) and MS-RDIR (3.78±0.34, P<0.001), and better quality (3.96±0.52) than MS-DIR (3.61±0.40, P=0.023).
SS-RDIR with ACS reconstruction offers substantially shorter scan time and superior image quality than traditional multi-shot techniques. This approach enhances clinical workflow and patient comfort, facilitating a broader application of DB-FSE in pediatric cardiac imaging.
黑血T2加权快速自旋回波（DB-FSE）对运动敏感，在小儿心脏自由呼吸成像中会导致信号丢失伪影和鬼影伪影，严重影响其诊断质量。在此，我们旨在通过基于人工智能（AI）辅助压缩感知（ACS）重建的反向双反转恢复（RDIR）和单次激发DB-FSE相结合，在自由呼吸过程中实现高分辨率的运动稳健性水肿评估。
这项前瞻性研究纳入了20名健康儿童和47名儿科患者。比较了三种成像技术：基于双反转恢复的常规多次激发DB-FSE（MS-DIR）、基于RDIR的多次激发DB-FSE（MS-RDIR）以及基于RDIR并采用ACS重建的单次激发DB-FSE（SS-RDIR）。通过定量指标（包括总采集时间、信噪比（SNR）和对比噪声比（CNR））以及定性指标（包括心肌可见性、鬼影伪影和整体质量）对这些方法进行比较。
在健康儿童中，SS-RDIR的总采集时间（秒）（64.8±21.8）显著短于MS-DIR（222.5±69.3，P<0.001）和MS-RDIR（234.0±64.1，P<0.001）。SNR和CNR具有可比性（SNR的P=0.094，CNR的P=0.054）。与MS-DIR（3.95±0.28，P<0.001）和MS-RDIR（3.97±0.31，P<0.001）相比，SS-RDIR中的鬼影伪影显著减少（4.70±0.18），而与MS-DIR（3.87±0.27，P=0.004）和MS-RDIR（3.95±0.34，P=0.010）相比，SS-RDIR的整体质量得到改善（4.42±0.19）。在患者中，与MS-DIR（62.1±24.0对216.6±74.2，P<0.001）和MS-RDIR（229.8±79.2，P<0.001）相比，SS-RDIR显著缩短了总采集时间，SNR（P=0.065）和CNR（P=0.089）具有可比性。与MS-DIR（3.77±0.29，P<0.001）和MS-RDIR（3.78±0.34，P<0.001）相比，SS-RDIR的鬼影伪影也较轻（4.94±0.11），且质量（3.96±0.52）优于MS-DIR（3.61±0.40，P=0.023）。
采用ACS重建的SS-RDIR比传统的多次激发技术提供了显著更短的扫描时间和更高的图像质量。这种方法增强了临床工作流程和患者舒适度，有助于DB-FSE在小儿心脏成像中的更广泛应用。
