Faraj Raid, El Bougrini Zineb, Benyass Aatif, Sekkach Youssef, Asfalou Ilyasse
Cardiology Center, Mohammed V Military Instruction Hospital of Rabat, Mohammed V University of Rabat, 10000 Rabat, Morocco.
Department of Internal Medicine, Cardiology Center, Mohammed V Military Instruction Hospital of Rabat, Mohammed V University of Rabat, 10000 Rabat, Morocco.
Eur Heart J Case Rep. 2025 May 2;9(5):ytaf218. doi: 10.1093/ehjcr/ytaf218. eCollection 2025 May.
Hypereosinophilic syndrome (HES) is an infrequent multisystemic disorder with a serious prognosis, defined by persistent marked eosinophilia (>1500 eosinophils/mm3) associated with organ damage from eosinophil-mediated cytotoxicity. Cardiac involvement is a significant and unpredictable complication of hypereosinophilic syndrome, particularly prevalent in patients carrying the FIP1L1-PDGFRA fusion.
Reported is a case of chronic eosinophilic leukaemia (CEL) with a FIP1L1-PDGFRA rearrangement, diagnosed in a 31-year-old patient presenting with Loeffler endocarditis. Intracardiac thrombi and embolic cerebral infarctions complicated the case. The patient demonstrated haematological remission following chemotherapy, and anticoagulation treatment led to thrombi resolution.
This case highlights that Loeffler endocarditis can present as the primary and sole manifestation of chronic eosinophilic leukaemia. Effective collaboration between cardiologists and internists is crucial for timely diagnosis and comprehensive management, ultimately resulting in enhanced outcomes.
高嗜酸性粒细胞综合征（HES）是一种罕见的多系统疾病，预后严重，其定义为持续性显著嗜酸性粒细胞增多（>1500个嗜酸性粒细胞/mm³）并伴有嗜酸性粒细胞介导的细胞毒性导致的器官损伤。心脏受累是高嗜酸性粒细胞综合征的一种重要且不可预测的并发症，在携带FIP1L1-PDGFRA融合基因的患者中尤为常见。
报告了一例31岁患有Löffler心内膜炎的FIP1L1-PDGFRA重排慢性嗜酸性粒细胞白血病（CEL）患者。心内血栓和栓塞性脑梗死使病情复杂化。患者化疗后血液学缓解，抗凝治疗使血栓溶解。
该病例强调Löffler心内膜炎可作为慢性嗜酸性粒细胞白血病的主要且唯一表现。心脏病专家和内科医生之间的有效协作对于及时诊断和综合管理至关重要，最终可改善预后。
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