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使用垂直可扩展人工钛肋(VEPTR)对先天性早发性脊柱侧弯进行手术治疗:病例系列

Operative management of congenital early-onset scoliosis using the vertical expandable prosthetic titanium rib (VEPTR): a case series.

作者信息

Mohammed Riaz, Shah Pranav, Jones Alwyn, Ahuja Sashin, Howes John

机构信息

Spine Surgery, University Hospital of Wales, Cardiff, UK.

Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, England, UK.

出版信息

World J Pediatr Surg. 2025 May 13;8(2):e000972. doi: 10.1136/wjps-2024-000972. eCollection 2025.

DOI:10.1136/wjps-2024-000972
PMID:40385246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12083380/
Abstract

To analyze surgical challenges and outcomes in patients who completed the whole journey of vertical expandable prosthetic titanium rib (VEPTR) treatment for congenital early-onset scoliosis (C-EOS), given the limited evidence available on VEPTR graduates. A retrospective review was conducted on nine consecutive patients with C-EOS and thoracic hypoplasia treated at a single tertiary care center, with assessment of clinical and radiological outcomes. At mean duration of 7.4 (range 4.3-10.5) years of VEPTR treatment, the mean coronal deformity angle measured 65° preoperatively, 50° postoperatively, and 58° at final follow-up. Mean T1-S1 length (pre-op 252 mm, final follow-up 333 mm) and T1-T12 length (preop 128 mm, final follow-up 196 mm) improved by 32% at final follow-up. Mean space available for lung was 86% (range 79%-93%) preoperatively, increasing to 90% (range 85%-95%) postoperatively and 97% (range 87%-107%) at final follow-up. Nine children had a cumulative 17 (188%) complications comprising wound problems, infection, and device migration or prominence. In five patients who underwent definitive fusion, mean coronal deformity angle and T1-S1 length improved by 17% and 11%, respectively. VEPTR is valuable in managing EOS, particularly in patients with thoracic insufficiency syndrome. However, the need for multiple surgeries, limited correction potential, and risk of partial loss of correction make it less suitable for other cases.

摘要

鉴于关于垂直可扩展人工钛肋骨(VEPTR)治疗先天性早发性脊柱侧凸(C-EOS)全程治疗患者的手术挑战和结果的证据有限,对其进行分析。对在单一三级医疗中心接受治疗的9例连续的C-EOS和胸廓发育不全患者进行回顾性研究,评估临床和放射学结果。在VEPTR治疗的平均7.4年(范围4.3 - 10.5年)时,术前平均冠状面畸形角度为65°,术后为50°,末次随访时为58°。末次随访时,平均T1-S1长度(术前252 mm,末次随访333 mm)和T1-T12长度(术前128 mm,末次随访196 mm)改善了32%。术前肺可用空间平均为86%(范围79% - 93%),术后增加到90%(范围85% - 95%),末次随访时为97%(范围87% - 107%)。9名儿童共发生17例(188%)并发症,包括伤口问题、感染以及器械移位或突出。在5例接受确定性融合手术的患者中,平均冠状面畸形角度和T1-S1长度分别改善了17%和11%。VEPTR在治疗EOS方面具有价值,特别是对于胸廓功能不全综合征患者。然而,需要多次手术、有限的矫正潜力以及部分矫正丢失的风险使其不太适合其他病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15cb/12083380/a37d34539f90/wjps-8-2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15cb/12083380/58ca9d8e3960/wjps-8-2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15cb/12083380/a37d34539f90/wjps-8-2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15cb/12083380/58ca9d8e3960/wjps-8-2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15cb/12083380/a37d34539f90/wjps-8-2-g002.jpg

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本文引用的文献

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VEPTR Treatment of Early Onset Scoliosis in Children Without Rib Abnormalities: Long-term Results of a Prospective, Multicenter Study.VEPTR治疗无肋骨异常儿童早发性脊柱侧弯:一项前瞻性多中心研究的长期结果
J Pediatr Orthop. 2020 Jul;40(6):e406-e412. doi: 10.1097/BPO.0000000000001454.
2
Long term outcome of vertical expandable prosthetic titanium rib treatment in children with early onset scoliosis.早期脊柱侧凸患儿垂直可扩展人工钛肋骨治疗的长期疗效
Ann Transl Med. 2020 Jan;8(2):25. doi: 10.21037/atm.2019.09.158.
3
Idiopathic Early-onset Scoliosis: Growing Rods Versus Vertically Expandable Prosthetic Titanium Ribs at 5-year Follow-up.
特发性早发性脊柱侧弯:5年随访中生长棒与可垂直扩展的人工钛肋骨对比研究
J Pediatr Orthop. 2020 Mar;40(3):142-148. doi: 10.1097/BPO.0000000000001202.
4
Radiographic Outcome and Complication Rate of 34 Graduates After Treatment With Vertical Expandable Prosthetic Titanium Rib (VEPTR): A Single Center Report.34例接受垂直可扩展人工钛肋(VEPTR)治疗的患者的影像学结果及并发症发生率:一项单中心报告
J Pediatr Orthop. 2019 Nov/Dec;39(10):e731-e736. doi: 10.1097/BPO.0000000000001338.
5
Risk Factors for Surgical Site Infections Following Vertical Expandable Prosthetic Titanium Rib (VEPTR) Surgery in Children.儿童垂直可扩张人工钛肋骨(VEPTR)手术后手术部位感染的危险因素
Spine Deform. 2018 Nov-Dec;6(6):791-796. doi: 10.1016/j.jspd.2018.03.016.
6
A comparison of growth among growth-friendly systems for scoliosis: a systematic review.不同脊柱侧凸生长友好型系统的生长比较:系统评价。
Spine J. 2019 May;19(5):789-799. doi: 10.1016/j.spinee.2018.08.017. Epub 2018 Oct 2.
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Parallel Proximal Fixation in Rib-Based Growing Rod System: A Novel Approach to Deal With Proximal Anchor Migration.肋骨基生长棒系统中的平行近端固定:一种处理近端锚定迁移的新方法。
Spine (Phila Pa 1976). 2018 Jul 15;43(14):E855-E858. doi: 10.1097/BRS.0000000000002527.
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Evolution of the postoperative sagittal spinal profile in early-onset scoliosis: is there a difference between rib-based and spine-based growth-friendly instrumentation?早发性脊柱侧弯术后矢状面脊柱形态的演变:基于肋骨和基于脊柱的生长友好型内固定器械之间存在差异吗?
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