吡非尼酮的疗效与安全性洞察：特发性肺纤维化的治疗
Insight into the efficacy and safety of pirfenidone: The treatment of idiopathic pulmonary fibrosis.
作者信息
Xu Li-Ying, Yu Yi, Cen Lu-Sha
机构信息
Department of Medical Administration, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang Province, China.
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310051, Zhejiang Province, China.
出版信息
World J Clin Cases. 2025 May 16;13(14):98769. doi: 10.12998/wjcc.v13.i14.98769.
Idiopathic pulmonary fibrosis (IPF) has a poor prognosis if left untreated; therefore, early treatment with pirfenidone is crucial. Lei conducted a retrospective analysis to evaluate the effectiveness of early pirfenidone treatment on lung function in 113 patients with IPF. In addition to other research, pirfenidone has demonstrated efficacy in patients at all stages of IPF once correct diagnosis has been made. In advanced IPF, we include the requirement for pirfenidone. Therefore, it is essential to choose an appropriate method of administration method, such as inhalation. This may circumvent the drawbacks of the high cost and possible adverse effects of this drug.
特发性肺纤维化（IPF）若不治疗，预后较差；因此，尽早使用吡非尼酮治疗至关重要。Lei进行了一项回顾性分析，以评估早期使用吡非尼酮治疗对113例IPF患者肺功能的有效性。除其他研究外，一旦确诊，吡非尼酮已在IPF各阶段的患者中显示出疗效。在晚期IPF中，我们纳入了使用吡非尼酮的要求。因此，选择合适的给药方法至关重要，如吸入给药。这可能会规避该药物成本高和可能产生的不良反应等缺点。
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