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镓标记的FAPI PET在一名播散性诺卡菌病肾移植患者中的应用——一种用于感染成像的有价值的成像方式

Ga FAPI PET in a Renal Transplant Patient with Disseminated Nocardiosis-A Worthwhile Imaging Modality for Infection Imaging.

作者信息

Kumar Srinivas Ananth, Subramanian Karthikeyan, Mittal Bhagwant Rai, Singh Harmandeep, Kumar Rajender, Singh Sarbpreet

机构信息

Department of Nuclear Medicine and PET/CT, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 India.

²Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Nucl Med Mol Imaging. 2025 Jun;59(3):209-211. doi: 10.1007/s13139-024-00897-8. Epub 2024 Dec 29.

Abstract

Nocardiosis, an opportunistic infection occurs in immunodeficient population commonly in organ transplant recipients. Patients with risk factors likely chronic corticosteroids and immunosuppressants consumption usually have a higher tendency for disseminated infections with formation of deep abscesses at various sites in the body. Functional imaging with PET, being a whole body imaging offers information about the various sites of disease, thereby assisting the treatment planning, treatment response and also to identify the sites of biopsy. 68Ga FAPI PET serves this purpose as previous studies in various other infections have shown activated fibroblasts with increased FAP expression at the infective foci.

摘要

诺卡菌病是一种机会性感染,常见于免疫功能低下人群,尤其是器官移植受者。有危险因素的患者,如长期使用皮质类固醇和免疫抑制剂,通常更容易发生播散性感染,并在身体各个部位形成深部脓肿。正电子发射断层显像(PET)功能成像作为一种全身成像,可提供有关疾病各个部位的信息,从而有助于治疗方案的制定、治疗反应评估,还能确定活检部位。68Ga 纤维母细胞激活蛋白(FAPI)PET 就能起到这样的作用,因为此前在其他各种感染中的研究表明,感染灶处的成纤维细胞被激活,FAP 表达增加。

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