Systemic acyclovir in pregnancy: a case report.

Disseminated herpes simplex infection in pregnancy presents serious risk to mother and fetus. Although an uncommon problem, the high maternal and fetal mortality and morbidity accompanying disseminated herpes infection warrants aggressive new treatment. Specific antiviral chemotherapy is now possible for selected cases. The present report describes the use of acyclovir during the third trimester for disseminated herpes simplex infection. The treatment protocol used and pregnancy outcome are described for this case. Acyclovir therapy and potential toxicities are described.