Tang Jinling, Hou Zhaojuan, Liao Wei, Wang Yuwei, Zhang Ge, Luo Yangyang, Gao Xiaofei, Wei Zhu
Department of Dermatology, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, 410007, People's Republic of China.
Center for Reproductive Medicine, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, People's Republic of China.
Psoriasis (Auckl). 2025 May 12;15:185-195. doi: 10.2147/PTT.S519385. eCollection 2025.
Pustular psoriasis (PP) is a systemic inflammatory disease that rarely occurs in children but adversely affects their quality of life.
This study aimed to evaluate the clinical characteristics, treatment, prognosis, and epidemiology of PP in pediatrics.
A single center retrospective study on 41 children diagnosed with PP was conducted in a university-affiliated referral hospital between January 2010 and May 2022. The demographics, clinical characteristics, treatment, and prognosis were evaluated in the descriptive analysis. To further investigate the effect of different acitretin-based treatments on the prognosis, 38 patients were included in the subgroup analysis. Patients who received acitretin alone were designated as the Acitretin group, while those who received acitretin combined with intravenous immunoglobulin, ciclosporin, or steroids (or any combination of these agents) were identified as the Combination group.
A total of 41 patients were enrolled in the descriptive analysis. Of these, 65.8% (27/41) were male, and the mean age of onset was 3.2 ± 3.2 years. Among the patients, 63.4% (26/41) presented with pustules, and over half experienced fever and elevated C-reactive protein (CRP) levels. In the subgroup analysis, the CRP level was significantly higher in the Combination group (59.69 ± 43.74 versus 26.35 ± 19.67 mg/dL, P = 0.006), indicating that patients had more severe inflammatory conditions. Nevertheless, there was no significant difference in the remission rate between the Acitretin group and the Combination group.
Pediatric PP is a disease that often occurs in the pre-school period and predominantly affects males. It is characterized by typical skin lesions and systemic inflammatory reactions. Common comorbidities include nutritional disorders such as malnutrition and anemia. Combination treatment based on acitretin is recommended for children with PP and severe inflammation.
脓疱型银屑病（PP）是一种全身性炎症性疾病，在儿童中很少见，但会对他们的生活质量产生不利影响。
本研究旨在评估儿科脓疱型银屑病的临床特征、治疗、预后和流行病学情况。
2010年1月至2022年5月期间，在一家大学附属医院对41例诊断为脓疱型银屑病的儿童进行了单中心回顾性研究。在描述性分析中评估了人口统计学、临床特征、治疗和预后情况。为了进一步研究不同的阿维A治疗对预后的影响，38例患者纳入亚组分析。单独接受阿维A治疗的患者被指定为阿维A组，而接受阿维A联合静脉注射免疫球蛋白、环孢素或类固醇（或这些药物的任何组合）治疗的患者被确定为联合治疗组。
共有41例患者纳入描述性分析。其中，65.8%（27/41）为男性，平均发病年龄为3.2±3.2岁。在这些患者中，63.4%（26/41）出现脓疱，超过一半的患者有发热和C反应蛋白（CRP）水平升高。在亚组分析中，联合治疗组的CRP水平显著更高（59.69±43.74对26.35±仃9.67mg/dL，P = 0.006），表明患者的炎症状况更严重。然而，阿维A组和联合治疗组之间的缓解率没有显著差异。
儿童脓疱型银屑病是一种常在学龄前发病且主要影响男性的疾病。其特征为典型的皮肤病变和全身性炎症反应。常见的合并症包括营养不良和贫血等营养障碍。对于患有脓疱型银屑病且炎症严重的儿童，建议采用基于阿维A的联合治疗。
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