Popadic Svetlana, Nikolic Milos
Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
Pediatr Dermatol. 2014 Sep-Oct;31(5):575-9. doi: 10.1111/pde.12296. Epub 2014 Mar 6.
Pustular psoriasis (PP) is rare in children. The small number of reported cases makes deciding on treatment and follow-up challenging. The current study was an evaluation of treatment approaches and courses of PP in 18 children diagnosed and followed over a 20-year period. From 1992 to 2011 we treated 1,447 children with psoriasis, 18 of whom had PP. Follow-up was 2 to 19 years. At the time of initial manifestation of PP, our patients were 1.5 months to 16 years old. Seven patients had a previous history of psoriasis vulgaris. Three children entered long-term remission after one pustular attack, 10 developed psoriasis vulgaris, 2 are currently under treatment, and 3 were lost to follow-up. Treatment with acitretin, cyclosporine, or methotrexate was efficacious and well tolerated. PP is rare, but according to our experience, it has a good prognosis in children.
脓疱型银屑病（PP）在儿童中较为罕见。已报道的病例数量较少，这使得治疗决策和随访颇具挑战性。本研究评估了18例在20年期间被诊断并接受随访的儿童PP的治疗方法和病程。1992年至2011年，我们共治疗了1447例银屑病患儿，其中18例为PP。随访时间为2至19年。PP初次出现时，我们的患者年龄为1.5个月至16岁。7例患者既往有寻常型银屑病病史。3例患儿在一次脓疱发作后进入长期缓解期，10例发展为寻常型银屑病，2例目前正在接受治疗，3例失访。阿维A、环孢素或甲氨蝶呤治疗有效且耐受性良好。PP虽罕见，但根据我们的经验，其在儿童中预后良好。
