Messanga Bessala Rostand Dimitri, Vugugah Vuchichi Boris, Ngo Kam Erna Hosanna
Public Health, Newcastle University, Newcastle Upon Tyne, GBR.
Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, CMR.
Cureus. 2025 Apr 17;17(4):e82427. doi: 10.7759/cureus.82427. eCollection 2025 Apr.
Introduction Gastrointestinal symptoms (GIS) are commonly reported in individuals with chronic kidney disease (CKD) and can significantly impact quality of life (QoL). Despite this, data from sub-Saharan Africa remain scarce. This study aimed to evaluate the effect of GIS on QoL in CKD patients in Cameroon. Materials and methods A cross-sectional study was carried out between December 2021 and May 2022 at the Yaounde General Hospital and Yaounde University Teaching Hospital. Participants included adults (≥18 years) with CKD stages III-V or on hemodialysis. GIS were assessed using a Modified Rome IV Diagnostic Questionnaire, and QoL was measured with the Gastrointestinal Quality of Life Index (GIQLI). Associations and correlations between GIS, QoL, and clinical characteristics were analyzed using Spearman's correlation and multiple regression, with significance set at p<0.05. Results Among 202 participants (median age 58 years, 63.4% male), 82.2% reported at least one GIS. The most common symptoms were anorexia (41.1%), constipation (39.6%), nausea (36.6%), bloating (33.7%), and vomiting (32.2%). QoL showed a weak negative correlation with serum creatinine (rho=-0.36; p<0.001) and a weak positive correlation with estimated glomerular filtration rate (eGFR) (rho=0.40; p<0.001). GIS and hypertension were significantly associated with lower QoL scores. Specifically, the presence of GIS (aOR=0.17; CI: 0.06-0.40; p<0.001) and hypertension (aOR=0.35; CI: 0.13-0.85; p=0.02) reduced the odds of better QoL. Conclusion GIS are prevalent among CKD patients in Cameroon and are linked to diminished QoL. Reduced renal function and hypertension further compound this effect. Routine QoL assessments and symptom-targeted interventions should be integrated into clinical care to enhance patient outcomes.
引言 胃肠道症状（GIS）在慢性肾脏病（CKD）患者中很常见，并且会显著影响生活质量（QoL）。尽管如此，撒哈拉以南非洲地区的数据仍然稀缺。本研究旨在评估GIS对喀麦隆CKD患者生活质量的影响。 材料与方法 2021年12月至2022年5月期间，在雅温得综合医院和雅温得大学教学医院开展了一项横断面研究。参与者包括CKD III-V期或接受血液透析的成年人（≥18岁）。使用改良的罗马IV诊断问卷评估GIS，并使用胃肠道生活质量指数（GIQLI）测量生活质量。使用Spearman相关性分析和多元回归分析GIS、生活质量和临床特征之间的关联及相关性，显著性设定为p<0.05。 结果 在202名参与者中（中位年龄58岁，63.4%为男性），82.2%报告至少有一种GIS。最常见的症状是厌食（41.1%）、便秘（39.6%）、恶心（36.6%）、腹胀（33.7%）和呕吐（32.2%）。生活质量与血清肌酐呈弱负相关（rho=-0.36；p<0.001），与估计肾小球滤过率（eGFR）呈弱正相关（rho=0.40；p<0.001）。GIS和高血压与较低的生活质量评分显著相关。具体而言，存在GIS（调整后比值比[aOR]=0.17；可信区间[CI]：0.06-0.40；p<0.001）和高血压（aOR=0.35；CI：0.13-0.85；p=0.02）会降低生活质量更好的几率。 结论 GIS在喀麦隆的CKD患者中普遍存在，并且与生活质量下降有关。肾功能降低和高血压会进一步加剧这种影响。应将常规生活质量评估和针对症状的干预措施纳入临床护理，以改善患者预后。
