某些铂化合物的抗肿瘤活性。
Antitumour activity of some platinum compounds.
作者信息
Chakraborty B K, Biswas N, Choudhury K, Neogy R K, Das Sarma B
出版信息
Chemotherapy. 1985;31(1):55-9. doi: 10.1159/000238314.
A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it binds to DNA, but transcription is not the primary process inhibited by these compounds. The drug-DNA complex, though less toxic, was not more effective than the free drug.
合成了一组顺式乙二胺铂（II）配合物，并测试了它们对小鼠肉瘤-180腹水肿瘤细胞的活性。其中一种化合物，Pt(HOCH2CH2NHCH2CH2NH2)Cl2，显示出显著的抗肿瘤活性，对宿主毒性很小。与母体化合物顺铂一样，它与DNA结合，但转录不是这些化合物抑制的主要过程。药物-DNA复合物虽然毒性较小，但并不比游离药物更有效。
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