Linz Valerie Catherine, Breuer Alina, Leppert Philipp, Herm-Stapelberg Nils, Schwarzer Katja, Hasenburg Annette
Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Mainz, Germany.
Krebsregister Rheinland-Pfalz im Institut für digitale Gesundheitsdaten RLP, Mainz, Germany.
Geburtshilfe Frauenheilkd. 2025 May 15;85(5):541-547. doi: 10.1055/a-2555-4602. eCollection 2025 May.
Serous tubal intraepithelial carcinomas (STIC) are classified as precursor lesions of high-grade serous carcinomas (HGSC) in women. STIC are rare and their incidence, prognosis and therapy remain unclear. Since 2021, all cases of isolated STIC in Germany must be reported, which means that all STICs in the German federal state of the Rhineland-Palatine (RLP) are available for evaluation.
A systematic search of the pathology reports in the RLP cancer registry was carried out for the period 01/2016-12/2023 using keywords related to STIC, and the results of the search were evaluated.
382 pathology reports were identified as relevant and screened. A total of seven patients with isolated STIC were reported to the RLP registry in the years 2020-2022. This corresponds to 0.014% of all reported cases of cancer in women in RLP in this period. Six patients had a diagnosis of isolated STIC, identified during risk-reducing salpingo-oophorectomy (RRSO). The mean patient age at the time of RRSO was 60.29 (± 7.09) years. RRSO was carried out on average 9.38 (± 6.75) years after a primary diagnosis of breast cancer/DCIS in five patients. No HGSC was reported for any of the patients with isolated STIC in the follow-up period until 01/2024. 43 synchronous STICs were reported for the period from 01/2016 to 12/2023.
2-3 diagnoses of isolated STIC were recorded annually in RLP in the years 2020-2022. To date, there have been no reports of HGSC in these patients. In the future, the systematic recording of STICs will be expanded to include the cancer registries of other federal states of Germany and it will be possible to obtain valid data on the incidence of STIC in Germany. The collected data will also provide the basic information for a national STIC registry.
浆液性输卵管上皮内癌（STIC）被归类为女性高级别浆液性癌（HGSC）的前驱病变。STIC较为罕见，其发病率、预后和治疗方法仍不明确。自2021年起，德国所有孤立性STIC病例均须上报，这意味着德国莱茵兰-普法尔茨州（RLP）的所有STIC病例都可供评估。
利用与STIC相关的关键词，对RLP癌症登记处2016年1月至2023年12月期间的病理报告进行系统检索，并对检索结果进行评估。
共识别并筛选出382份相关病理报告。2020年至2022年期间，共有7例孤立性STIC患者上报至RLP登记处。这相当于该时期RLP所有上报女性癌症病例的0.014%。6例患者在降低风险的输卵管卵巢切除术（RRSO）期间被诊断为孤立性STIC。RRSO时患者的平均年龄为60.29（±7.09）岁。5例患者在首次诊断乳腺癌/导管原位癌（DCIS）后平均9.38（±6.75）年接受了RRSO。在截至2024年1月 的随访期内，任何孤立性STIC患者均未报告发生HGSC。2016年1月至2023年12月期间报告了43例同步性STIC。
2020年至2022年期间，RLP每年记录2至3例孤立性STIC诊断病例。迄今为止，这些患者尚无HGSC报告。未来，STIC的系统记录将扩大到德国其他联邦州的癌症登记处，从而有可能获得德国STIC发病率的有效数据。收集到的数据还将为国家STIC登记处提供基础信息。
