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Changes in tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), matrix metallopeptidase-2/9 (MMP-2/9), and T-lymphocyte subsets in patients undergoing thoracoscopic surgery under refined management for non-small-cell lung cancer.

作者信息

Cai Shuxin, Zhang Yannan

机构信息

Affiliated Hospital of Nantong University, Department of Thoracic Surgery, Nantong, China.

出版信息

J Med Biochem. 2025 Mar 21;44(2):277-286. doi: 10.5937/jomb0-51316.

DOI:10.5937/jomb0-51316
PMID:40386525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085174/
Abstract

BACKGROUND: Non-small-cell lung cancer (NSCLC) remains one of the most common malignancies worldwide, posing a great potential threat to the health and life safety of patients. METHODS: One hundred and fifty NSCLC patients admitted to our hospital from September 2022 to September 2023 were selected whose inflammatory response and changes in T-lymphocyte subpopulations before and after surgery were detected, and patients' psychological status was investigated. Finally, patients were followed up for 6 months to record the prognostic survival rate. RESULTS: Postoperative inflammatory factors and CD8 + were lower in the research group than in the control group, while CD3 + , CD4 + and CD4 + /CD8 + were higher than in the control group (P<0.05). Meanwhile, the psychological status of the research group was better. However, the two groups did not differ in prognostic survival (P>0.05). CONCLUSIONS: Perioperative refinement of care can optimize the surgical process in patients with NSCLC, and the cellular immune function was enhanced.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/9809209343d1/jomb-44-2-2502277C_g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/7f1e9e119245/jomb-44-2-2502277C_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/763a0898499e/jomb-44-2-2502277C_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/70a5ee29dce1/jomb-44-2-2502277C_g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/e82663f4dc7c/jomb-44-2-2502277C_g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/9809209343d1/jomb-44-2-2502277C_g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/7f1e9e119245/jomb-44-2-2502277C_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/763a0898499e/jomb-44-2-2502277C_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/70a5ee29dce1/jomb-44-2-2502277C_g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/e82663f4dc7c/jomb-44-2-2502277C_g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb0/12085174/9809209343d1/jomb-44-2-2502277C_g005.jpg

相似文献

[1]
Changes in tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), matrix metallopeptidase-2/9 (MMP-2/9), and T-lymphocyte subsets in patients undergoing thoracoscopic surgery under refined management for non-small-cell lung cancer.

J Med Biochem. 2025-3-21

[2]
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J Surg Oncol. 2023-9

[3]
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[4]
[Effect of Pembrolizumab on T Lymphocyte Subsets in Patients with Advanced 
Non-small Cell Lung Cancer and Its Therapeutic Effect].

Zhongguo Fei Ai Za Zhi. 2021-3-20

[5]
Association of lymphocyte subsets with efficacy and prognosis of immune checkpoint inhibitor therapy in advanced non-small cell lung carcinoma: a retrospective study.

BMC Pulm Med. 2022-4-28

[6]
Clinical Efficacy of Different Thoracoscopic Surgeries for Patients With Non-small Cell Lung Cancer.

Front Surg. 2022-2-15

[7]
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Technol Cancer Res Treat. 2021

[8]
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Front Immunol. 2023

[9]
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[10]
Functional status and spatial interaction of T cell subsets driven by specific tumor microenvironment correlate with recurrence of non-small cell lung cancer.

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本文引用的文献

[1]
Analysis of variation of serum CEA, SCC, CYFRA21-1 in patients with lung cancer and their diagnostic value with EBUS-TBNA.

J Med Biochem. 2024-6-15

[2]
The effect of enhanced recovery after lung cancer surgery combined with fine surgical nursing on rehabilitation.

J Pak Med Assoc. 2024-5

[3]
Cinobufotalin effect and mechanism on serum MMP-2, MMP-9, Beclin1, LC3-II in advanced NSCLC patients.

Cell Mol Biol (Noisy-le-grand). 2023-12-31

[4]
Advances and challenges in the treatment of lung cancer.

Biomed Pharmacother. 2023-12-31

[5]
ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis.

BMC Cancer. 2023-11-14

[6]
MMP-2 and its implications on cardiac function and structure: Interplay with inflammation in hypertension.

Biochem Pharmacol. 2023-9

[7]
Investigating Genetic Factors and the Effect of Refined Multidisciplinary Clinical Management on the Quality of Life and Perceived Control Level of Breast Cancer Patients undergoing Surgery and its Morphological Diagnosis Parameters.

Cell Mol Biol (Noisy-le-grand). 2023-4-30

[8]
Lung Cancer Supportive Care and Symptom Management.

Hematol Oncol Clin North Am. 2023-6

[9]
Lung Cancer Treatment Advances in 2022.

Cancer Invest. 2023-1

[10]
Perioperative Systemic Therapy for Resectable Non-Small Cell Lung Cancer.

J Natl Compr Canc Netw. 2022-8

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