Rice D C
Toxicol Appl Pharmacol. 1985 Feb;77(2):201-10. doi: 10.1016/0041-008x(85)90319-9.
Cynomolgus monkeys (Macaca fascicularis) were dosed from birth with 100, 50, or 0 micrograms/kg/day of lead. This protocol resulted in blood lead concentrations of 25, 15, or 3 micrograms/dl, respectively, before withdrawal of infant formula at 200 days of age. Blood lead concentration declined thereafter over the next 100 to 150 days to steady-state levels of 13, 11, or 3 micrograms/dl. At approximately 3 years of age, monkeys were tested on a series of three discrimination reversal tasks: nonspatial form discrimination, nonspatial color discrimination with irrelevant form cues, and nonspatial form discrimination with irrelevant color cues. The higher dose group was impaired relative to controls over the entire experiment (all three tasks combined), the two form discrimination tasks combined, and the form discrimination with no irrelevant cues. Deficits were most marked over the first several reversals. The lower dose group was impaired on the color discrimination task and on the last several reversals of all tasks combined. In addition, the higher dose group was impaired relative to the lower dose group over the entire experiment.
食蟹猴（猕猴）从出生起每天分别接受100、50或0微克/千克的铅剂量。该方案导致在200日龄停止婴儿配方奶粉喂养前，血铅浓度分别为25、15或3微克/分升。此后，血铅浓度在接下来的100至150天内下降至13、11或3微克/分升的稳态水平。在大约3岁时，对猴子进行了一系列三项辨别反转任务测试：非空间形状辨别、带有无关形状线索的非空间颜色辨别以及带有无关颜色线索的非空间形状辨别。在整个实验（三项任务综合）、两项形状辨别任务综合以及无无关线索的形状辨别中，高剂量组相对于对照组表现受损。在最初的几次反转中缺陷最为明显。低剂量组在颜色辨别任务以及所有任务综合的最后几次反转中表现受损。此外，在整个实验中，高剂量组相对于低剂量组表现受损。
