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Leveraging Transcriptional Readouts as a Platform for Drug Repurposing in Cardiomyopathy.

作者信息

Mahmoud Ahmed I, Sadek Hesham A

机构信息

Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (A.I.M.).

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (H.A.S.).

出版信息

Circulation. 2025 May 20;151(20):1449-1450. doi: 10.1161/CIRCULATIONAHA.125.074556. Epub 2025 May 19.

Abstract
摘要

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本文引用的文献

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Olmesartan Restores Function in Haploinsufficient Cardiomyocytes.
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2
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study.
Circulation. 2023 Sep 12;148(11):872-881. doi: 10.1161/CIRCULATIONAHA.123.064847. Epub 2023 Aug 29.
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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Nature. 2019 Aug;572(7769):335-340. doi: 10.1038/s41586-019-1406-x. Epub 2019 Jul 17.
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Cell. 2017 Nov 30;171(6):1437-1452.e17. doi: 10.1016/j.cell.2017.10.049.
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