Watts J F, Butt W R, Logan Edwards R, Holder G
Br J Obstet Gynaecol. 1985 Mar;92(3):247-55. doi: 10.1111/j.1471-0528.1985.tb01090.x.
Serum hormone concentrations were determined at intervals during the last 17 days of the menstrual cycle in 35 patients with premenstrual tension (PMT) and 11 control subjects without symptoms. The maximum mean concentration of oestradiol occurred 17 days before menstruation in the patients and 14 days before in the controls. The maximum concentrations of progesterone were similar in the two groups but the mean concentrations rose earlier in the cycle in the patients with PMT. These results suggested that the patients tended to ovulate earlier in the cycle than the controls and on the basis of the ovulatory surge in gonadotrophins two groups could be identified, group A who showed signs of ovulation 14 days or less before menstruation (17 patients, 9 controls) and group B who ovulated more than 14 days before menstruation (18 patients, 2 controls). There were no significant differences between the groups in prolactin, thyroid stimulating hormone or testosterone levels, but cortisol concentrations were uniformly higher in both groups of patients compared with those in the controls. Follicular growth was assessed with ultrasound in 18 patients and 16 control subjects. Mean follicular diameters were significantly lower in the patients than in the control group at the time of ovulation. Oestradiol determinations done at the same time correlated with the diameters and were also significantly lower in the patient group. The results suggest that ovulation tends to occur prematurely in women with PMT.
在月经周期的最后17天，对35例经前紧张综合征（PMT）患者和11例无症状对照者的血清激素浓度进行了定期测定。雌二醇的最大平均浓度在患者中出现在月经前17天，在对照者中出现在月经前14天。两组孕酮的最大浓度相似，但PMT患者组孕酮的平均浓度在月经周期中上升得更早。这些结果表明，患者比对照者在月经周期中排卵更早，根据促性腺激素的排卵高峰，可将两组患者区分开来，A组在月经前14天或更短时间出现排卵迹象（17例患者，9例对照者），B组在月经前14天以上排卵（18例患者，2例对照者）。两组患者在催乳素、促甲状腺激素或睾酮水平上无显著差异，但两组患者的皮质醇浓度均高于对照者。对18例患者和16例对照者进行超声检查评估卵泡生长情况。排卵时患者的平均卵泡直径显著低于对照组。同时进行的雌二醇测定与卵泡直径相关，患者组的雌二醇水平也显著低于对照组。结果表明，PMT女性排卵往往过早。
