Li Jianfeng, Fang Yu, Li Qihua, Zeng Chen, Jiang Yuchen, Kong Weiqing, Zhu Meifang
State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
Int J Biol Macromol. 2025 Jun;314:144109. doi: 10.1016/j.ijbiomac.2025.144109. Epub 2025 May 17.
Stimuli-responsive microcapsules enable controlled release of core materials in response to environmental triggers, offering greater application potential than conventional systems, particularly in smart textiles and drug delivery. However, challenges persist in enhancing encapsulation efficiency, stability, and achieving sustained, controllable release under specific environmental conditions. In this study, dual cross-linked chitosan nanocapsules (DC) encapsulating Lavender essential oils were synthesized through a combination of electrostatic interactions between chitosan and sodium tripolyphosphate and Schiff base reactions between chitosan and glutaraldehyde. The resulting nanocapsules, approximately 50 nm in size, exhibited an encapsulation efficiency of 93.18 % and a loading capacity of 14.54 %. They demonstrated sustained release, retaining 77.11 % of their content after 36 days at room temperature, as well as notable thermal stability. Additionally, under alkaline conditions (pH = 10), the nanocapsules showed enhanced release rates, confirming their pH-responsive behavior. When loaded onto cotton fabrics via electrostatic adsorption, the functionalized fabrics exhibited slow-release properties. These findings highlight the potential of dual cross-linked chitosan nanocapsules as multifunctional and innovative delivery systems for diverse applications.
刺激响应性微胶囊能够根据环境触发因素实现核心材料的可控释放，与传统系统相比具有更大的应用潜力，尤其是在智能纺织品和药物递送领域。然而，在提高包封效率、稳定性以及在特定环境条件下实现持续、可控释放方面仍存在挑战。在本研究中，通过壳聚糖与三聚磷酸钠之间的静电相互作用以及壳聚糖与戊二醛之间的席夫碱反应，合成了包封薰衣草精油的双交联壳聚糖纳米胶囊（DC）。所得纳米胶囊尺寸约为50nm，包封效率为93.18%，载药量为14.54%。它们表现出持续释放，在室温下36天后仍保留77.11%的含量，并且具有显著的热稳定性。此外，在碱性条件（pH = 10）下，纳米胶囊显示出更高的释放速率，证实了它们的pH响应行为。当通过静电吸附负载到棉织物上时，功能化织物表现出缓释性能。这些发现突出了双交联壳聚糖纳米胶囊作为多功能创新递送系统在各种应用中的潜力。
