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[甲状腺髓样癌的最新进展——对外科医生有何重要意义?]

[Update on medullary thyroid carcinoma-What is relevant for surgeons?].

作者信息

Lorenz Kerstin, Machens Andreas, Dralle Henning

机构信息

Klinik für Viszerale, Gefäß- und Endokrine Chirurgie, Universitätsmedizin Halle, Ernst-Grube-Str. 40, 06120, Halle/Saale, Deutschland.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Division Endokrine Chirurgie, Universität Duisburg-Essen, Essen, Deutschland.

出版信息

Chirurgie (Heidelb). 2025 May 19. doi: 10.1007/s00104-025-02289-w.

DOI:10.1007/s00104-025-02289-w
PMID:40389686
Abstract

This article provides an overview of surgically relevant diagnostic and operative aspects of medullary thyroid carcinoma (MTC) regarding current trends from recent studies and the expected adaptation of national S3 guidelines. The article addresses individual patient treatment options based on recognizable risk factors, the intraoperative resection strategy and standard procedures as well as the characteristics of sporadic and hereditary MTC with the concept of prophylactic thyroidectomy.

摘要

本文概述了甲状腺髓样癌(MTC)在手术相关诊断和手术方面的当前趋势,这些趋势来自近期研究以及国家S3指南的预期调整。本文基于可识别的风险因素阐述了个体患者的治疗选择、术中切除策略和标准程序,以及散发型和遗传性MTC的特征与预防性甲状腺切除术的概念。

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本文引用的文献

1
Incidence and distribution of neck node metastases in hereditary vs. sporadic medullary thyroid cancer at basal calcitonin serum levels ≤100 pg/ml: 30-year experience.基础降钙素血清水平≤100 pg/ml时遗传性与散发性甲状腺髓样癌颈部淋巴结转移的发生率及分布:30年经验
Eur J Surg Oncol. 2025 Jul;51(7):109756. doi: 10.1016/j.ejso.2025.109756. Epub 2025 Mar 7.
2
CTR-FAPI PET Enables Precision Management of Medullary Thyroid Carcinoma.CTR-FAPI PET助力甲状腺髓样癌的精准管理。
Cancer Discov. 2025 Feb 7;15(2):316-328. doi: 10.1158/2159-8290.CD-24-0897.
3
Origin and impact of multifocal growth in sporadic vs. hereditary medullary thyroid cancer.
散发性与遗传性髓样甲状腺癌中多灶性生长的起源和影响。
Eur J Surg Oncol. 2024 Nov;50(11):108625. doi: 10.1016/j.ejso.2024.108625. Epub 2024 Aug 29.
4
The role of [18F]F-DOPA PET/CT in diagnostic and prognostic assessment of medullary thyroid cancer: a 15-year experience with 109 patients.[18F]F-DOPA PET/CT 在诊断和预后评估甲状腺髓样癌中的作用:109 例患者 15 年的经验。
Eur Thyroid J. 2024 Jul 13;13(4). doi: 10.1530/ETJ-24-0089. Print 2024 Aug 1.
5
Tumor desmoplasia outperforms preoperative serum calcitonin as surgical biomarker in sporadic medullary thyroid cancer.促纤维增生性肿瘤比术前降钙素更能作为散发性甲状腺髓样癌的手术生物标志物。
Head Neck. 2024 Nov;46(11):2843-2852. doi: 10.1002/hed.27827. Epub 2024 Jun 8.
6
Anatomical Patterns of Nodal Spread in Unilateral Papillary and Medullary Thyroid Cancer.单侧甲状腺乳头状癌和髓样癌的淋巴结转移解剖模式。
Thyroid. 2024 Jul;34(7):871-879. doi: 10.1089/thy.2024.0076. Epub 2024 May 21.
7
Latest Progress in Risk-Adapted Surgery for Medullary Thyroid Cancer.甲状腺髓样癌风险适应性手术的最新进展
Cancers (Basel). 2024 Feb 24;16(5):917. doi: 10.3390/cancers16050917.
8
[Individualization of treatment in sporadic and hereditary medullary thyroid cancer].[散发性和遗传性甲状腺髓样癌的个体化治疗]
Chirurgie (Heidelb). 2024 Mar;95(3):186-191. doi: 10.1007/s00104-023-02015-4. Epub 2024 Jan 12.
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Phase 3 Trial of Selpercatinib in Advanced -Mutant Medullary Thyroid Cancer.塞尔帕替尼治疗晚期突变型甲状腺髓样癌的 3 期临床试验。
N Engl J Med. 2023 Nov 16;389(20):1851-1861. doi: 10.1056/NEJMoa2309719. Epub 2023 Oct 21.
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Sporadic noninvasive medullary thyroid neoplasm: A desmoplasia-negative unifocal nonmetastatic tumor cured by hemithyroidectomy.散发性无侵袭性甲状腺髓样癌:无促结缔组织增生的单灶性非转移性肿瘤,行半甲状腺切除术可治愈。
Surgery. 2023 Dec;174(6):1356-1362. doi: 10.1016/j.surg.2023.09.003. Epub 2023 Oct 10.