Pradhan Rupesh Kumar, Singh Sulochana
Department of Chemistry, ITER, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
BMC Chem. 2025 May 19;19(1):133. doi: 10.1186/s13065-025-01490-6.
The interactions between amino acids and saccharides in aqueous environments are fascinating and have significant implications for various fields. These interactions can provide valuable insights into physiological processes, drug targeting, and delivery systems. To comprehend the synergy between saccharide (L-arabinose D-xylose) and non-essential amino acid (L-aspartic acid; Asp) in an aqueous system, ultrasonic velocity ( ) at 293.15 K-313.15 K (with 5 K interval) and at experimental pressure P = 101 kPa were measured using a digital ultrasonic interferometer. The solution density, and the propagation of sound waves through the experimental solutions are directly correlated with the weak and strong molecular interactions that take place between the solution's constituents. and data was utilised to compute the following acoustic parameters isentropic compressibility , apparent molar isentropic compressibility free volume , free length , internal pressure , acoustic impedance , surface tension and relative association . Positive values make ion-solvent interactions stronger than ion-ion interactions. Positive values of imply greater interactions between the polar segments of L-arabinose/D-xylose and the zwitterionic groups of Asp. The solvation mechanisms of Asp result in the reconstruction of the water structure. The FTIR technique was used to verify the results of the acoustic study. The presence of intermolecular hydrogen bonding and intramolecular hydrogen bonding is shown by the broadening of the absorption band. The system under research exhibits predominant ion-hydrophilic hydrophilic interactions as confirmed by FTIR analysis. Understanding how Asp in aqueous environment interacts with saccharides such as L-arabinose and D-xylose might help one better understand how these molecules behave in biological systems.
氨基酸与糖类在水性环境中的相互作用引人入胜，对各个领域都具有重要意义。这些相互作用可为生理过程、药物靶向和递送系统提供有价值的见解。为了理解糖类（L-阿拉伯糖、D-木糖）与非必需氨基酸（L-天冬氨酸；Asp）在水体系中的协同作用，使用数字超声干涉仪在293.15 K至313.15 K（间隔5 K）以及实验压力P = 101 kPa下测量了超声速度（ ）。溶液密度 以及声波在实验溶液中的传播与溶液成分之间发生的强弱分子相互作用直接相关。利用 和 数据计算了以下声学参数：等熵压缩率 、表观摩尔等熵压缩率 、自由体积 、自由长度 、内压 、声阻抗 、表面张力 和相对缔合度 。正的 值表明离子-溶剂相互作用强于离子-离子相互作用。 的正值意味着L-阿拉伯糖/D-木糖的极性片段与Asp的两性离子基团之间存在更强的相互作用。Asp的溶剂化机制导致水结构的重构。采用傅里叶变换红外光谱（FTIR）技术验证声学研究结果。吸收带变宽表明存在分子间氢键和分子内氢键。FTIR分析证实，所研究的体系表现出主要的离子-亲水、亲水相互作用。了解水性环境中的Asp如何与L-阿拉伯糖和D-木糖等糖类相互作用，可能有助于人们更好地理解这些分子在生物系统中的行为。
