Chronic inflammation is a prolonged immune response that contributes to various diseases, including neuropathies, autoimmune conditions, and metabolic disorders. This review explores the role of chronic inflammation across multiple medical specialties, emphasizing its impact on diseases such as chronic inflammatory demyelinating polyneuropathy (CIDP), rheumatoid arthritis (RA), and chronic hepatitis. It highlights common inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and C-reactive protein (CRP), which drive tissue damage and disease progression. Infections, particularly viral and bacterial agents, trigger inflammatory responses through mechanisms such as molecular mimicry and bystander activation, leading to chronic pain and neuropathy. While current treatments, including corticosteroids and biologics, offer some relief, they are often limited by side effects and insufficient symptom resolution. This review suggests that future therapeutic strategies should focus on targeted inflammation modulation, bioelectronic medicine, and early intervention. Addressing the multifaceted nature of chronic inflammatory syndromes is crucial for improving patient outcomes and quality of life.