Bhatta Uma, Lopez-Calderon Leslie
Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, USA.
Cureus. 2025 Apr 19;17(4):e82586. doi: 10.7759/cureus.82586. eCollection 2025 Apr.
Primary pulmonary colloid adenocarcinoma (PPCA) is a rare variant of lung adenocarcinoma characterized by abundant extracellular mucin production, often posing diagnostic challenges due to its slow growth and nonspecific imaging findings. We present the case of a 77-year-old male with a medical history of coronary artery disease (CAD) and congestive heart failure (CHF), who exhibited a gradually enlarging right lower lobe lung mass over eight years. Initial imaging and biopsy results were inconclusive, but a subsequent biopsy following surgical resection confirmed the diagnosis of PPCA. This case highlights the clinical challenges, pathological features, and diagnostic complexities for elderly patients with this rare type of lung carcinoma. It emphasizes the crucial role of surgical resection in its management.
原发性肺黏液腺癌（PPCA）是肺腺癌的一种罕见变体，其特征是产生大量细胞外黏液，由于其生长缓慢和影像学表现不具特异性，常常给诊断带来挑战。我们报告一例77岁男性病例，该患者有冠状动脉疾病（CAD）和充血性心力衰竭（CHF）病史，其右下肺叶肿块在八年中逐渐增大。最初的影像学和活检结果不明确，但手术切除后的后续活检确诊为PPCA。该病例突出了老年患者患这种罕见类型肺癌的临床挑战、病理特征和诊断复杂性。它强调了手术切除在其治疗中的关键作用。
