Commandeur Susanna, van der Most Marleen, Koomen Jeroen, van Keulen Lucien, Dinkla Annemieke, Luinenburg Xander, Escher Marieke, Jacobs Pieter, Keur Ingrid, Grinwis Guy C M, Weerts Erik, Broens Els M, Anthony Richard, Agterveld Miranda Kamst-van, Rebel Karin, Huisman Erik, Heijne Marloes, Koets Ad
Department of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the Netherlands.
Netherlands Food and Consumer Product Safety Authority (NVWA), P.O. Box 43006, 3540 AA Utrecht, the Netherlands.
One Health. 2025 Apr 21;20:101048. doi: 10.1016/j.onehlt.2025.101048. eCollection 2025 Jun.
Although the Netherlands is an officially bovine tuberculosis (bTB) free (OTF) country, sporadic infections with still cause tuberculosis (TB) in (non-bovine) mammals, including humans. We describe for the first time cases of infection in domestic cats in the Netherlands with transmission between companion animals and humans. In January 2023, a domestic cat, euthanized due to severe respiratory clinical signs, was diagnosed with . Subsequently, three other cats from the household were euthanized and also diagnosed with . The remaining kitten and dog received antibiotic treatment. Human contacts were screened using Tuberculin Skin Test (TST) and Interferon-Gamma Release Assay (IGRA). Lung lesions were detected in a TST/IGRA contact which tested positive for DNA. This human lung-derived DNA contained single nucleotide polymorphisms (SNPs) that were also identified in the DNA of isolated from the cats in this household, strengthening the hypothesis of intra-species transmission within the household. The four TST human contacts received antibiotic treatment. In the same period, another domestic cat from an unrelated household was euthanized due to respiratory clinical signs and diagnosed with . This strain differed 500 SNPs from the strains of the first household and was therefore genetically distinct. Commercially available, ready-to-use raw pet food was a suspected source in both households, however this could not be confirmed. These cases illustrate the need for one-health vigilance among both veterinarians and human physicians as essential to control outbreaks and prevent further spread to humans, companion animals, wildlife and livestock.
尽管荷兰是官方认定的无牛结核病（bTB）国家，但 （某种病菌）的零星感染仍会在包括人类在内的（非牛类）哺乳动物中引发结核病（TB）。我们首次描述了荷兰家猫感染 （病菌）的病例，以及该病菌在伴侣动物和人类之间的传播情况。2023年1月，一只因严重呼吸道临床症状而被安乐死的家猫被诊断感染了 （病菌）。随后，该家庭中的另外三只猫也被安乐死，并被诊断感染了 （病菌）。剩下的小猫和小狗接受了抗生素治疗。对人类接触者进行了结核菌素皮肤试验（TST）和干扰素-γ释放试验（IGRA）筛查。在一名TST/IGRA检测呈阳性且 （病菌）DNA检测呈阳性的接触者的肺部发现了病变。该人类肺部来源的 （病菌）DNA中所含的单核苷酸多态性（SNP）也在从该家庭的猫身上分离出的 （病菌）DNA中被发现，这强化了病菌在家庭内部进行种内传播的假设。这四名TST检测呈阳性的人类接触者接受了抗生素治疗。同一时期，另一个家庭的一只家猫因呼吸道临床症状被安乐死，并被诊断感染了 （病菌）。该 （病菌）菌株与第一个家庭的菌株有500个SNP的差异，因此在基因上是不同的。在这两个家庭中，市售的即食宠物生食都被怀疑是传染源，然而这一点无法得到证实。这些病例表明，兽医和人类医生都需要保持“同一健康”警惕性，这对于控制疫情爆发以及防止病菌进一步传播给人类、伴侣动物、野生动物和家畜至关重要。
