清酒处理大鼠的血浆支链氨基酸异常

Plasma branched chain amino acid abnormalities in sake-treated rats.

作者信息

Watanabe A, Nakatsukasa H, Kobayashi M, Nagashima H

出版信息

Acta Med Okayama. 1985 Feb;39(1):67-71. doi: 10.18926/AMO/31545.

Abstract

Plasma amino acid abnormalities in rats treated with large doses of sake and whisky for 3 days were investigated under adequate nutritional conditions. A significant decrease in plasma branched-chain amino acid (BCAA) levels was observed in sake- but not whisky-treated rats. However, known factors affecting BCAA levels, such as serum insulin and plasma glucagon levels ahd BCAA-metabolizing enzyme (BCAA transaminase and branched chain alpha-ketoacid dehydrogenase) activities in the liver and skeletal muscle, were not significantly altered in the sake group. Furthermore, ethanol-metabolizing enzyme (alcohol and aldehyde dehydrogenases and the microsomal ethanol-oxidizing system) activities in the liver were not altered in the sake group. Other mechanisms need to be considered for explaining the diminished levels of plasma BCAA in sake-treated rats.

摘要

在充足营养条件下，研究了大剂量清酒和威士忌处理3天的大鼠血浆氨基酸异常情况。在经清酒处理而非威士忌处理的大鼠中，观察到血浆支链氨基酸（BCAA）水平显著降低。然而，影响BCAA水平的已知因素，如血清胰岛素和血浆胰高血糖素水平，以及肝脏和骨骼肌中BCAA代谢酶（BCAA转氨酶和支链α-酮酸脱氢酶）的活性，在清酒组中并未显著改变。此外，肝脏中乙醇代谢酶（醇脱氢酶、醛脱氢酶和微粒体乙醇氧化系统）的活性在清酒组中也未改变。需要考虑其他机制来解释经清酒处理的大鼠血浆BCAA水平降低的现象。