INTRODUCTION: Today, there is an emphasis on considering the individual needs and preferences of the patient in education and care. This study aims to assess the effect of individualized education on hemodialysis adequacy (Kt/V) and interdialytic weight gain (IDWG) in patients undergoing hemodialysis (HD). METHODS: 102 HD patients were randomly assigned to the intervention or control groups. Patients in the intervention group (n=51) received individualized education. The control group (n=51) received routine education. The patients' dialysis adequacy (Kt/V) and IDWG were assessed before the intervention, immediately, and three months after the last session of individualized education. Data were analyzed using SPSS software. RESULTS: A significant increase in Kt/V was found in the intervention group compared with the control group immediately and three months after the intervention (<0.05). Moreover, the mean total score of IDWG in the intervention group was significantly lower than the control group immediately and three months after the intervention (<0.05). CONCLUSION: The results highlighted the importance of individualized education for improving HD adequacy and lowering IDWG in HD patients. Moreover, it is recommended to tailor the patients' education based on their own needs, rather than a one-size-fits-all approach.