Müller H, Zulliger H W
Arzneimittelforschung. 1985;35(1):152-4.
A sensitive, specific and rapid determination of 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid sodium salt dihydrate (zomepirac sodium, Zomax) in human plasma and urine by a continuous body fluid monitoring system based on high-performance liquid chromatography is described. Samples are directly injected into the apparatus which consists of commonly available HPLC-modules. Manual sample clean-up procedures as well as the addition of an internal standard are not needed. Using 50-microliter aliquots, the detection limit is lower than 0.05 microgram/ml and the calibration ranges from 0.5 to 100 micrograms/ml are linear for both, spiked samples and references. The recovery is 97% for plasma and 95% for urine samples at a sampling rate of about 15 samples/h.
描述了一种基于高效液相色谱的连续体液监测系统，用于灵敏、特异且快速地测定人血浆和尿液中的5-(4-氯苯甲酰基)-1,4-二甲基-1H-吡咯-2-乙酸钠盐二水合物（佐美酸，佐马克）。样品直接注入由常用高效液相色谱模块组成的仪器中。无需手动样品净化程序以及添加内标。使用50微升等分试样，检测限低于0.05微克/毫升，加标样品和参比样品的校准范围在0.5至100微克/毫升之间呈线性。在约每小时15个样品的采样速率下，血浆回收率为97%，尿液样品回收率为95%。
