胃肠道恶性肿瘤中的脂质代谢：探索失调、生物标志物和治疗策略
Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies.
作者信息
An Yan, Song Huihui, Qiu Hongyan, Jiang Jun, Shi Junfeng
机构信息
Department of Anesthesiology, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Obstetrical Medicine Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
出版信息
Cancer Med. 2025 May;14(10):e70975. doi: 10.1002/cam4.70975.
BACKGROUND
Gastrointestinal malignancies are a major public health concern worldwide, characterized by high incidence and mortality rates. Despite continuous advancements in existing treatment methods, overall survival rates remain low. Lipid metabolism plays a crucial role in the occurrence, progression, and treatment of gastrointestinal malignancies. Its involvement in the metabolic reprogramming of tumor cells, regulation of the tumor microenvironment, and drug response has become a research hotspot.
MATERIALS & METHODS: This review summarizes current research related to lipid metabolism mechanisms, biomarkers, and therapies in GI cancers, with emphasis on its interaction with the tumor microenvironment.
背景
胃肠道恶性肿瘤是全球主要的公共卫生问题，其发病率和死亡率都很高。尽管现有治疗方法不断进步，但总体生存率仍然很低。脂质代谢在胃肠道恶性肿瘤的发生、发展和治疗中起着关键作用。它参与肿瘤细胞的代谢重编程、肿瘤微环境的调节以及药物反应，已成为研究热点。
材料与方法
本综述总结了目前关于胃肠道癌症中脂质代谢机制、生物标志物和治疗方法的研究，重点关注其与肿瘤微环境的相互作用。
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