• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

细菌药物靶点的结构基因组学：应用高通量流程解析58种致病及相关细菌的蛋白质结构

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

作者信息

Inniss Nicole L, Minasov George, Chang Changsoo, Tan Kemin, Kim Youngchang, Maltseva Natalia, Stogios Peter, Filippova Ekaterina, Michalska Karolina, Osipiuk Jerzy, Jaroszewki Lukasz, Godzik Adam, Savchenko Alexei, Joachimiak Andrzej, Anderson Wayne F, Satchell Karla J F

机构信息

Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Center for Structural Biology of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

出版信息

Microbiol Resour Announc. 2025 Jun 12;14(6):e0020025. doi: 10.1128/mra.00200-25. Epub 2025 May 20.

DOI:10.1128/mra.00200-25
PMID:40391899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12160482/
Abstract

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

摘要

抗生素耐药性仍然是全球严重感染的主要原因。蛋白质序列的微小变化会影响抗生素疗效。在此，我们报告了58种细菌蛋白质的X射线晶体结构的存贮情况，这些蛋白质是已知的抗生素作用靶点，这拓展了结构变异方面的知识，以支持未来的抗生素发现或改良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b5/12160482/311d2b1f3a60/mra.00200-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b5/12160482/311d2b1f3a60/mra.00200-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b5/12160482/311d2b1f3a60/mra.00200-25.f001.jpg

相似文献

1
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.细菌药物靶点的结构基因组学：应用高通量流程解析58种致病及相关细菌的蛋白质结构
Microbiol Resour Announc. 2025 Jun 12;14(6):e0020025. doi: 10.1128/mra.00200-25. Epub 2025 May 20.
2
Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal.抗生素耐药菌：现状与治疗选择，以加速新抗菌药物的研发。
Expert Rev Anti Infect Ther. 2022 Aug;20(8):1095-1108. doi: 10.1080/14787210.2022.2078308. Epub 2022 May 31.
3
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.靶向结核杆菌：一种通过相互作用组、反应组和基因组规模结构分析来鉴定结核分枝杆菌靶点的流程
BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
4
Metabolic pathway analysis approach: identification of novel therapeutic target against methicillin resistant Staphylococcus aureus.代谢途径分析方法：针对耐甲氧西林金黄色葡萄球菌新型治疗靶点的鉴定
Gene. 2015 Feb 10;556(2):213-26. doi: 10.1016/j.gene.2014.11.056. Epub 2014 Nov 28.
5
Genomic tools to profile antibiotic mode of action.用于剖析抗生素作用模式的基因组学工具。
Crit Rev Microbiol. 2015;41(4):465-72. doi: 10.3109/1040841X.2013.866073. Epub 2014 Mar 12.
6
Structural genomics and drug discovery for infectious diseases.传染病的结构基因组学与药物发现
Infect Disord Drug Targets. 2009 Nov;9(5):507-17. doi: 10.2174/187152609789105713.
7
Structural genomics approach to drug discovery for Mycobacterium tuberculosis.用于结核分枝杆菌药物发现的结构基因组学方法。
Curr Opin Microbiol. 2009 Jun;12(3):318-25. doi: 10.1016/j.mib.2009.04.006. Epub 2009 May 28.
8
Bacterial Pathogens: Potential Source For Antimicrobial Peptides.细菌病原体：抗菌肽的潜在来源。
Curr Protein Pept Sci. 2023;24(7):551-566. doi: 10.2174/1389203724666230726100303.
9
The structural genomics experimental pipeline: insights from global target lists.结构基因组学实验流程：来自全球目标列表的见解
Proteins. 2004 Aug 1;56(2):201-10. doi: 10.1002/prot.20060.
10
Vesicoureteral Reflux膀胱输尿管反流

本文引用的文献

1
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.2019 年全球细菌对抗菌药物耐药性的负担：系统分析。
Lancet. 2022 Feb 12;399(10325):629-655. doi: 10.1016/S0140-6736(21)02724-0. Epub 2022 Jan 19.
2
Structural and functional characterization of three Type B and C chloramphenicol acetyltransferases from Vibrio species.三种弧菌属 B 型和 C 型氯霉素乙酰转移酶的结构与功能特征。
Protein Sci. 2020 Mar;29(3):695-710. doi: 10.1002/pro.3793. Epub 2019 Dec 6.
3
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix.
利用 X 射线、中子和电子进行高分子结构测定： Phenix 的最新进展。
Acta Crystallogr D Struct Biol. 2019 Oct 1;75(Pt 10):861-877. doi: 10.1107/S2059798319011471. Epub 2019 Oct 2.
4
Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases.恶臭假单胞菌对羟基苯甲酸羟化酶（PobA）与其他假单胞菌属的PobA及其他单加氧酶的结构比较。
Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):507-514. doi: 10.1107/S2053230X19008653. Epub 2019 Jul 2.
5
Parallel protein purification.并行蛋白质纯化
Methods Mol Biol. 2014;1140:137-43. doi: 10.1007/978-1-4939-0354-2_10.
6
Protein production for structural genomics using E. coli expression.利用大肠杆菌表达进行结构基因组学的蛋白质生产。
Methods Mol Biol. 2014;1140:89-105. doi: 10.1007/978-1-4939-0354-2_7.
7
REFMAC5 for the refinement of macromolecular crystal structures.用于大分子晶体结构精修的REFMAC5
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67. doi: 10.1107/S0907444911001314. Epub 2011 Mar 18.
8
Overview of the CCP4 suite and current developments.CCP4软件包概述及当前进展
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42. doi: 10.1107/S0907444910045749. Epub 2011 Mar 18.
9
Features and development of Coot.Coot的特点与发展
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501. doi: 10.1107/S0907444910007493. Epub 2010 Mar 24.
10
MolProbity: all-atom structure validation for macromolecular crystallography.MolProbity：用于大分子晶体学的全原子结构验证
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21. doi: 10.1107/S0907444909042073. Epub 2009 Dec 21.