Piteková Barbora, Hric Ivan, Baranovičová Eva, Zieg Jakub, Planet Paul J, Bielik Viktor
Department of Pediatric Emergency Medicine, National Institute of Children's Diseases, Bratislava, Slovakia.
Department of Pediatric Urology, Faculty of Medicine, Comenius University and National Institute of Children's Diseases, Bratislava, Slovakia.
Pediatr Nephrol. 2025 May 20. doi: 10.1007/s00467-025-06822-1.
Recurrent febrile urinary tract infections (fUTIs) in children can lead to serious complications such as renal scarring and progressive chronic kidney disease (CKD), with growing evidence indicating that gut microbiome dysbiosis may play a key role in their development. Fecal microbial transplantation (FMT) is an established therapeutic approach for restoring gut microbial balance; however, its use in patients with recurrent fUTIs remains limited and underexplored. This case study describes a 10-year-old boy with recurrent fUTIs and CKD secondary to a posterior urethral valve (PUV) anomaly. The patient was administered a total of seven doses of FMT. FMT reduced pathogenic Enterobacteriaceae, increased beneficial short-chain fatty acid (SCFA)-producing genera, and correspondingly raised SCFA levels, indicating restoration of gut microbiota balance. FMT presents an innovative therapeutic option for pediatric patients with recurrent fUTIs, demonstrating outstanding clinical outcomes.
儿童复发性发热性尿路感染（fUTIs）可导致严重并发症，如肾瘢痕形成和进行性慢性肾脏病（CKD），越来越多的证据表明肠道微生物群失调可能在其发展中起关键作用。粪便微生物移植（FMT）是一种恢复肠道微生物平衡的既定治疗方法；然而，其在复发性fUTIs患者中的应用仍然有限且研究不足。本病例研究描述了一名10岁男孩，因后尿道瓣膜（PUV）异常继发复发性fUTIs和CKD。该患者共接受了七次FMT治疗。FMT减少了致病性肠杆菌科细菌，增加了产生有益短链脂肪酸（SCFA）的菌属，并相应提高了SCFA水平，表明肠道微生物群平衡得到恢复。FMT为复发性fUTIs的儿科患者提供了一种创新的治疗选择，显示出出色的临床效果。
