Porta R, Fregnan G B
Arzneimittelforschung. 1977;27(1):118-22.
Kinetic studies were performed in rats, dogs and monkeys after oral administration of 14C-labelled dihydroxy-dibutyl ether (DHBE; Discinil), a known choleretic agent. The data presented indicate that the compound was intirely and readily absorbed and that it was excreted mainly with the urine in all the three species. The complete distribution pattern was investigated in rats. In most tissues high levels of radioactivity were already present after 10 min and the peak concentration was reached within the first 30 min. The decay was rapid and at the fourth hour only traces of radioactivity could be still detected in the tissues. Liver and kidney were the target organs for the radioactive material (which is in accordance with the activity and the excretory route of DHBE). The blood levels paralleled the general tissue distribution. The excretion of radioactivity was completed within 24 h in the three animal species and it took place by the urinary route, mainly witin the first 7--8 h.
在大鼠、狗和猴子口服14C标记的二羟基二丁醚（DHBE；利胆醇）（一种已知的利胆剂）后进行了动力学研究。所呈现的数据表明，该化合物完全且易于吸收，并且在所有这三个物种中主要通过尿液排泄。在大鼠中研究了其完整的分布模式。在大多数组织中，10分钟后就已存在高水平的放射性，并且在最初30分钟内达到峰值浓度。放射性衰减迅速，在第四小时时，在组织中仅能检测到痕量放射性。肝脏和肾脏是放射性物质的靶器官（这与DHBE的活性和排泄途径一致）。血液水平与总体组织分布情况相似。在这三种动物物种中，放射性排泄在24小时内完成，并且通过尿液途径进行，主要在最初的7 - 8小时内。
