Gad S C, Derelanko M J, Powers W J, Mulder S, Gavigan F, Babich P C
Fundam Appl Toxicol. 1985 Feb;5(1):128-36. doi: 10.1016/0272-0590(85)90056-9.
Dermal exposure of rabbits to cyclohexanone oxime (CHO) for 24 hr at 0, 0.8, 2, and 5 g/kg caused dose-related reticulocytosis on the day after dosing as well as a decrease in hemoglobin in the 5-g/kg females 7 days postdosing. Gavage of rats 5 days a week for 13 weeks at levels of 0, 0.25, 2.5, and 25 mg/kg resulted in a dose-related decrease in erythrocyte number, hemoglobin, and hematocrit, with an accompanying increase in circulating reticulocytes and nucleated erythrocytes, in both sexes. Also seen were corneal opacities and an increased incidence of Howell-Jolly bodies. Results suggested an increased erythropoiesis in the spleen and bone marrow. The data from satellite groups terminated at 30 and 60 days revealed no effect at the lower test level, but results from the end of the study showed a clear cumulative dose response down to the 0.25-mg/kg level. Males were affected earlier and at lower doses than females. These results, along with those of a subacute study with a recovery period, suggest that CHO induces an oxidative attack on erythrocytes which appears reversible upon cessation of exposure.
给家兔经皮暴露于环己酮肟（CHO），剂量分别为0、0.8、2和5 g/kg，持续24小时，给药后次日出现剂量相关的网织红细胞增多，且5 g/kg剂量组的雌性家兔在给药7天后血红蛋白降低。每周5天对大鼠进行13周的灌胃给药，剂量分别为0、0.25、2.5和25 mg/kg，结果导致两性大鼠的红细胞数量、血红蛋白和血细胞比容出现剂量相关的降低，同时循环网织红细胞和有核红细胞增加。还观察到角膜混浊以及豪焦小体发生率增加。结果提示脾脏和骨髓的红细胞生成增加。在30天和60天处死的卫星组的数据显示，在较低测试剂量下无影响，但研究结束时的结果显示，直至0.25 mg/kg剂量水平都有明显的累积剂量反应。雄性比雌性更早且在更低剂量下受到影响。这些结果，连同一项有恢复期的亚急性研究结果表明，CHO对红细胞诱导了氧化攻击，在停止暴露后这种攻击似乎是可逆的。
