[Animal experiments of neuroma treatment with histoacryl].

A neuroma arises due to uncoordinated growth of axis cylinders in proliferated granulation tissue. An intact perineurial tube prevents further growth of the funiculi. Animal experiments were designed to close the perineurial tube such that it was impervious to water. Earlier experiments with purse string suture of the perineurial tube or closure with Histoacryl were not always successful. After severance of the sciatic nerve of the rat and shortening of the axons, the epineurial tube was plugged with Histoacryl blue and closed so that it was impervious to water. The preparations were checked optically and histologically. The results were promising, so that this technique was applied clinically.