纳洛酮：一种对人体有效的凯托米酮拮抗剂。
Naloxone: a potent ketobemidone antagonist in man.
作者信息
Holst-Larsen H, Aasen A O, Rugstad H E
出版信息
Acta Pharmacol Toxicol (Copenh). 1979 Aug;45(2):91-5. doi: 10.1111/j.1600-0773.1979.tb02366.x.
Abstract
Naloxone has been accepted as a potent antagonist towards several narcotic analgesics, e.g. morphine, heroin and pethidin. Its effect as an antagonist and its potency against ketobemidone have not been tested in man. We have described the antagonistic effect of naloxone towards the respiratory depression caused by the administration of ketobemidone to patients anesthetized with N2O/O2 and methohexitone.
摘要
纳洛酮已被公认为是几种麻醉性镇痛药（如吗啡、海洛因和哌替啶）的有效拮抗剂。其作为拮抗剂的作用及其对凯托米酮的效力尚未在人体中进行测试。我们已经描述了纳洛酮对用N₂O/O₂和甲己炔巴比妥麻醉的患者注射凯托米酮所引起的呼吸抑制的拮抗作用。
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