Coughlin C T, Richmond R C
Int J Radiat Oncol Biol Phys. 1985 May;11(5):915-9. doi: 10.1016/0360-3016(85)90113-0.
Radiation therapy delivered soon after cisplatin administration is used for the treatment of advanced head and neck cancer. A radiation dose of 4800 cGy is given in standard fractions, followed by clinical evaluation and either surgical resection or an additional radiation dose of 2000 cGy. The histopathology of the surgical specimens from 21 patients undergoing resection in this protocol is compared with the corresponding clinical evaluation of tumor response. A significant number of both false negative and false positive clinical assessments are revealed by this comparison. In addition, it appears that local control of bulky head and neck cancer is approached by 4800 cGy combined soon after cisplatin. Discussion of the likely bases for this apparently favorable clinical interaction between cisplatin and radiation is presented.
顺铂给药后不久进行的放射治疗用于治疗晚期头颈癌。以标准分割方式给予4800厘戈瑞的放射剂量，随后进行临床评估，然后进行手术切除或额外给予2000厘戈瑞的放射剂量。将按照该方案接受切除的21例患者手术标本的组织病理学与相应的肿瘤反应临床评估进行比较。通过这种比较发现了大量假阴性和假阳性的临床评估。此外，似乎在顺铂给药后不久联合4800厘戈瑞可实现对体积较大的头颈癌的局部控制。文中还讨论了顺铂与放疗之间这种明显有利的临床相互作用的可能基础。
