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论人类胚胎与干细胞衍生胚胎模型的道德(不)等同性。

On the moral (in)equivalence of human embryos and stem cell-derived embryo models.

作者信息

de Graeff Nienke, De Proost Lien

机构信息

Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, The Netherlands

Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

J Med Ethics. 2025 May 19. doi: 10.1136/jme-2025-110866.

DOI:10.1136/jme-2025-110866
PMID:40393700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7617984/
Abstract

Gyngell argue that no intrinsic differences exist between stem cell-derived embryo models (SCEMs) and embryos derived from fertilisation that would justify attributing a higher moral status to the latter. Consequently, they claim there is no ethical rationale for treating SCEMs differently from embryos and contend that endorsing SCEMs as having moral advantages over embryos constitutes an obfuscation. In this commentary, we challenge the assertion that human SCEMs and embryos are morally equivalent by painting a more nuanced picture of the moral value of (different kinds of) SCEMs and embryos. First, we highlight the diversity among SCEMs, noting that different types of SCEMs need not be morally equivalent. This point is illustrated by taking a closer look at their potentiality, a property often considered relevant to moral status. Second, we observe that Gyngell , like much of the broader debate, primarily concentrate on the direct moral status of SCEMs in their analysis of the moral (in)equivalence with embryos. We argue that a comprehensive moral evaluation should encompass different types of moral value, evaluating not only direct moral status but also relational, symbolic and instrumental value. Ultimately, we suggest that the real obfuscation lies not in endorsing SCEMs as having moral advantages over embryos but rather in the overemphasis on direct moral status and the binary thinking about the moral (in)equivalence of embryos versus SCEMs that dominates these discussions.

摘要

金盖尔认为,干细胞衍生胚胎模型(SCEMs)与受精衍生胚胎之间不存在内在差异,这使得赋予后者更高的道德地位缺乏正当理由。因此,他们声称,没有伦理依据将SCEMs与胚胎区别对待,并认为支持SCEMs比胚胎具有道德优势是一种混淆视听的行为。在这篇评论中,我们通过对(不同类型的)SCEMs和胚胎的道德价值描绘出一幅更细致入微的图景,来质疑人类SCEMs和胚胎在道德上等同的断言。首先,我们强调SCEMs之间的多样性,指出不同类型的SCEMs在道德上不一定等同。通过仔细审视它们的潜能(一种常被认为与道德地位相关的属性)可以说明这一点。其次,我们注意到,与更广泛的辩论中的许多情况一样,金盖尔在分析与胚胎的道德(不)等同性时,主要关注SCEMs的直接道德地位。我们认为,全面的道德评估应涵盖不同类型的道德价值,不仅要评估直接道德地位,还要评估关系性、象征性和工具性价值。最终,我们认为真正的混淆不在于支持SCEMs比胚胎具有道德优势,而在于过度强调直接道德地位以及在这些讨论中占主导地位的关于胚胎与SCEMs道德(不)等同性的二元思维。

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本文引用的文献

1
Stem cell-derived embryo models: moral advance or moral obfuscation?干细胞衍生的胚胎模型:道德进步还是道德混淆?
J Med Ethics. 2025 May 21;51(6):361-364. doi: 10.1136/jme-2023-109605.
2
'Ceci n'est pas un embryon?' The ethics of human embryo model research.“这不是胚胎吗?”人类胚胎模型研究的伦理问题。
Nat Methods. 2023 Dec;20(12):1863-1867. doi: 10.1038/s41592-023-02066-9.
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Potentiality switches and epistemic uncertainty: the Argument from Potential in times of human embryo-like structures.潜能开关与认识不确定性:人类胚胎样结构时代的潜能论证。
Med Health Care Philos. 2024 Mar;27(1):37-48. doi: 10.1007/s11019-023-10181-9. Epub 2023 Oct 30.
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Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature.胚胎样体的伦理、法律、监管和政策问题:文献系统综述。
Stem Cell Res Ther. 2023 Aug 21;14(1):209. doi: 10.1186/s13287-023-03448-8.
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Developing a Reflexive, Anticipatory, and Deliberative Approach to Unanticipated Discoveries: Ethical Lessons from iBlastoids.发展一种反思性、前瞻性和深思熟虑的方法来应对意外发现:iBlastoids 带来的伦理教训。
Am J Bioeth. 2022 Jan;22(1):36-45. doi: 10.1080/15265161.2021.1974976. Epub 2021 Oct 1.
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Creating and sacrificing embryos for stem cells.为获取干细胞而制造和牺牲胚胎。
J Med Ethics. 2005 Jun;31(6):366-70. doi: 10.1136/jme.2004.008599.