Choi Tsun Man, Bruggink Robin, Hoekstra Jan Willem Mathijs, Mathijssen Irene Margreet Jacqueline, Wolvius Eppo Bonne, Ongkosuwito Edwin Mattheus
Erasmus Medical Centre, Department of Oral Maxillofacial Surgery, Special Dental Care and Orthodontics, Dutch Craniofacial Centre, PO Box 2040, 3000, CA, Rotterdam, the Netherlands.
Department of Dentistry, Section of Orthodontics and Craniofacial Biology, Radboud University Medical Centre, Nijmegen, the Netherlands; Radboudumc 3D Lab, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.
J Craniomaxillofac Surg. 2025 Aug;53(8):1205-1212. doi: 10.1016/j.jcms.2025.04.008. Epub 2025 May 19.
In craniosynostosis distinctive craniofacial and oral growth patterns are to be expected. This study aims to determine maxillary anomalies in craniosynostosis patients with Muenke syndrome, Saethre-Chotzen syndrome or TCF12-related craniosynostosis, using a three-dimensional semi-automated setup measurement of digital dental casts. Symmetry analysis of the maxilla of craniosynostosis patients was performed with creation of a reference frame, a palatal mesh and a distance map. The outline of the palate was determined by landmarks with the use of a semi-automated technique and software algorithm and compared to healthy controls. All transverse dimensions were smaller in the craniosynostosis group compared to the. control group (p < 0.001; canine premolar right TCF12 p = 0.005). In Muenke syndrome, the palate was higher compared to the control group (left and right; p < 0.001). In Saethre-Chotzen syndrome, the palate was shallower (left p < 0.001; right p = 0.003) and the left palatal surface was smaller compared to the control group (p < 0.001). This retrospective case-control study indicates that Muenke syndrome, Saethre-Chotzen syndrome and TCF12-related craniosynostosis have distinctive maxillary characteristics compared to healthy controls. Muenke syndrome had a higher arched palate. and Saethre-Chotzen had a shallower palate compared to healthy controls. The intersurface distance (ISD) in both syndromes indicated a palatal anomaly.
在颅缝早闭中，预期会出现独特的颅面和口腔生长模式。本研究旨在通过对数字化牙模进行三维半自动设置测量，确定患有穆恩克综合征、塞特雷-乔岑综合征或TCF12相关颅缝早闭的颅缝早闭患者的上颌骨异常情况。通过创建参考框架、腭部网格和距离图，对颅缝早闭患者的上颌骨进行对称分析。使用半自动技术和软件算法通过地标确定腭部轮廓，并与健康对照进行比较。与对照组相比，颅缝早闭组的所有横向尺寸均较小（p < 0.001；犬齿前磨牙右侧TCF12 p = 0.005）。在穆恩克综合征中，与对照组相比，腭部更高（左右两侧；p < 0.001）。在塞特雷-乔岑综合征中，腭部更浅（左侧p < 0.001；右侧p = 0.003），与对照组相比，左侧腭面更小（p < 0.001）。这项回顾性病例对照研究表明，与健康对照相比，穆恩克综合征、塞特雷-乔岑综合征和TCF12相关颅缝早闭具有独特的上颌骨特征。与健康对照相比，穆恩克综合征的腭弓更高，塞特雷-乔岑综合征的腭部更浅。两种综合征的表面间距离（ISD）均表明存在腭部异常。
