Guo Caihui, Xiong Zhenliang, Yang Lin, Bai Mingxian, Zhu Yi, Zeng Xianchun
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Department of Radiology, Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China.
Sci Rep. 2025 May 20;15(1):17444. doi: 10.1038/s41598-025-99406-w.
Brain functional changes and gut microbiota dysbiosis have been observed in perimenopausal syndrome (PMS). We evaluated the effects of a plant-based daily diet enriched with Raphanus sativus L. (RSL, radish seed) on the gut microbiota composition, gastrointestinal symptoms, resting-state local spontaneous brain activity, and neuropsychology in perimenopausal women. For 12 weeks, the participants were instructed to adhere to a controlled, Raphanus sativus L.-rich plant-based diet (a mean RSL intake of 5 g/day). Two test days were organized: before and after the nutritional intervention. The fecal microbiota composition, gastrointestinal symptoms, resting-state brain function, and neuropsychology were assessed twice. A longitudinal single-arm study was conducted on 24 perimenopausal women. The Montreal Cognitive Assessment (MoCA) scores tended to improve in the visuospatial/executive function subitem and in the total score after the diet. The participants presented elevated amplitude of low-frequency fluctuation (ALFF) values in the left middle occipital gyrus, the left precentral gyrus, and the left middle cingulum gyrus. The abundances of the phyla Synergistetes and Verrucomicrobia were positively correlated with the ALFF values of the left middle occipital gyrus, left precentral gyrus, and left middle cingulum gyrus. These data suggest that specific gut microbes may modulate intrinsic brain activity and cognitive function in perimenopausal women. A plant-based RSL-rich diet has beneficial effects on the gut microbial composition and brain function of perimenopausal women.
在围绝经期综合征（PMS）中已观察到脑功能变化和肠道微生物群失调。我们评估了富含萝卜籽（RSL）的植物性日常饮食对围绝经期女性肠道微生物群组成、胃肠道症状、静息态局部自发脑活动和神经心理学的影响。在12周内，指导参与者坚持一种受控的、富含萝卜籽的植物性饮食（平均每天摄入5克萝卜籽）。组织了两个测试日：营养干预前后各一次。对粪便微生物群组成、胃肠道症状、静息态脑功能和神经心理学进行了两次评估。对24名围绝经期女性进行了一项纵向单臂研究。饮食后，蒙特利尔认知评估（MoCA）分数在视觉空间/执行功能子项和总分上有改善趋势。参与者左侧枕中回、左侧中央前回和左侧扣带中回的低频振幅（ALFF）值升高。协同菌门和疣微菌门的丰度与左侧枕中回、左侧中央前回和左侧扣带中回的ALFF值呈正相关。这些数据表明，特定的肠道微生物可能调节围绝经期女性的内在脑活动和认知功能。富含萝卜籽的植物性饮食对围绝经期女性的肠道微生物组成和脑功能有有益影响。
