印度尼西亚人群中早孕期子痫前期联合筛查不同方法的性能比较。
Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population.
作者信息
Al Fattah Adly Nanda, Mahindra Muhammad Pradhiki, Yusrika Mirani Ulfa, Mapindra Muhammad Pradhika, Widjaja Felix Firyanto, Putri Vania Permata, Marizni Shinda, Hillman Sara L, Kusuma Raden Aditya
机构信息
Indonesian Prenatal Institute, Jakarta, Indonesia.
Kosambi Maternal and Children Center, Jakarta, Indonesia.
出版信息
J Perinatol. 2025 May 21. doi: 10.1038/s41372-025-02316-y.
INTRODUCTION
This study aimed to compare Fetal Medicine Foundation (FMF), Indonesian Maternal and Children Health Handbook (MCH-HB), and Indonesian Prenatal Institute (IPI) models for predicting PE.
MATERIALS/SUBJECTS AND METHODS: Maternal risk factors, biophysical, and biochemical markers were recorded from women screened for PE at 11-14 gestational weeks. The receiving operator curve (ROC) analysis was used to compare the detection rate (DR) among prediction models.
RESULTS
For all PE at a 10% false-positive rate (FPR), FMF had a DR 62.9%; MCH-HB had a DR 50.0%; IPI had a DR 66.9%. For early-onset PE, at 10% FPR FMF had a DR 80.3%; MCH-HB had a DR 71.4%; IPI had a DR 81.5%. For preterm PE at 10% FPR, FMF had a DR 70.2%; MCH-HB had a DR 38.5%; IPI had a DR 66.9%.
DISCUSSION
IPI algorithm is comparable to FMF and outperforms MCH-HB algorithm for all, early-onset, and preterm PE screening.
引言
本研究旨在比较胎儿医学基金会（FMF）、印度尼西亚母婴健康手册（MCH-HB）和印度尼西亚产前研究所（IPI）预测子痫前期（PE）的模型。
材料/研究对象与方法：记录孕11至14周接受子痫前期筛查的女性的母体危险因素、生物物理和生化指标。采用受试者工作特征曲线（ROC）分析比较各预测模型的检测率（DR）。
结果
对于所有子痫前期，在假阳性率（FPR）为10%时，FMF的检测率为62.9%；MCH-HB的检测率为50.0%；IPI的检测率为66.9%。对于早发型子痫前期，在FPR为10%时，FMF的检测率为80.3%；MCH-HB的检测率为71.4%；IPI的检测率为81.5%。对于早产型子痫前期，在FPR为10%时，FMF的检测率为70.2%；MCH-HB的检测率为38.5%；IPI的检测率为66.9%。
讨论
IPI算法与FMF相当，在所有、早发型和早产型子痫前期筛查方面均优于MCH-HB算法。
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