Nag S
Prostate. 1985;6(3):293-301. doi: 10.1002/pros.2990060309.
Localized cancer of the prostate can be treated by radical prostatectomy, external beam irradiation, or radioactive implantation with similar survival results. Radical prostatectomy, however, almost universally results in impotency, although a new, nerve-sparing procedure may preserve potency in B1 patients. External beam irradiation radiates a large volume of tissue with significant rectal and bladder morbidity, 23-47% risk of impotency, and requires prolonged treatment (6-8 weeks). Radioactive implantation may be done suprapubically or transperineally using iodine-125, gold-198, or radon-222 permanent implantation techniques and iridium-192 or radium-226 removable implantation techniques. Interstitial iodine-125 implantation is frequently employed since it is a short procedure and limits the morbidity to a 7% incidence of impotency, 20% urinary complications, and 5% rectal complications. The overall 5-year survival of patients with iodine-125 is 79%, the survival rate decreasing with increasing T or N stage or increasing grade of tumor.
局限性前列腺癌可通过根治性前列腺切除术、外照射或放射性粒子植入治疗，生存率相似。然而，根治性前列腺切除术几乎普遍会导致阳痿，不过一种新的保留神经的手术方法可能使B1期患者保留性功能。外照射会对大量组织进行辐射，导致明显的直肠和膀胱并发症，有23%至47%的阳痿风险，且需要较长时间的治疗（6至8周）。放射性粒子植入可经耻骨上或经会阴进行，使用碘-125、金-198或氡-222永久性植入技术以及铱-192或镭-226可移除植入技术。间质碘-125植入术经常被采用，因为它操作时间短，并发症发生率为：阳痿7%、泌尿系统并发症20%、直肠并发症5%。接受碘-125治疗的患者5年总生存率为79%，生存率会随着T或N分期增加或肿瘤分级升高而降低。
