Wu Chao, Zhang Zilong, Su Shuhong, Xu Haiyan, Song Lei, Wu Yongjian, Qiao Shubin, Wang Yang, Li Wei, Tang Yida, Gao Xiaojin, Yang Jingang, Yang Yuejin
Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China.
Coronary Heart Disease Center, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, No.167 North Lishi Road, Xicheng District, Beijing, China.
BMC Cardiovasc Disord. 2025 May 20;25(1):385. doi: 10.1186/s12872-025-04840-3.
Sweating in individuals with suspected cardiac chest pain indicates a greater risk of experiencing ST-segment elevation myocardial infarction (STEMI). Nevertheless, the relationship between sweating and clinical outcomes remains inadequately explored.
From 2013 through 2016, 19112 patients with STEMI enrolled in the China Acute Myocardial Infarction registry. Heavy sweating was evaluated on admission and usually judged by dampen clothing. Thrombolysis in Myocardial Infarction (TIMI) flow and ST-segment resolution (STR) were used to evaluated the myocardial reperfusion after primary percutaneous myocardial infarction (PCI). The primary outcome was all-cause death during hospitalization and at 24 months.
Thirteen thousand, four hundred twenty-two patients (70.2%) presented heavy sweating, that was associated with age < 65 years, severe chest pain, current smoking status, and heart rates < 100 bpm on admission. Heavy sweating group was more likely to achieve primary PCI (44.7% vs 32.9%) but shown similar rates of post-PCI TIMI 3 flow (95.5% vs 94.1%) and STR ≥ 50% (79.8% vs 78.2%). After multivariable analysis, heavy sweating was significantly linked to lower in-hospital (5.9% vs 8.6%, odds ratio [OR]: 0.81, 95% confidence interval [CI]: 0.72-0.92) and 24-month mortality (11.0% vs 17.2%, hazard ratio [HR]: 0.75, 95% CI: 0.69-0.82). Even among patients undergoing primary PCI who achieved successful myocardial reperfusion, this short- (2.5% vs 4.2%, OR: 0.60, 95% CI: 0.45-0.80) and long-term (5.9% vs 8.7%, HR: 0.68, 95% CI: 0.56-0.83) prognostic significance remained robust.
For STEMI, the presence of heavy sweating was associated with lower mortality regardless of successful primary PCI, which highlight the potential for early risk stratification based on the sweating presentation.
https//www.
gov. Unique identifier: NCT01874691. Registered 11/06/2013.
疑似心脏性胸痛患者出汗表明发生ST段抬高型心肌梗死（STEMI）的风险更高。然而，出汗与临床结局之间的关系仍未得到充分研究。
2013年至2016年，19112例STEMI患者纳入中国急性心肌梗死注册研究。入院时评估大汗情况，通常根据衣物潮湿程度判断。采用心肌梗死溶栓（TIMI）血流和ST段回落（STR）评估直接经皮冠状动脉介入治疗（PCI）后的心肌再灌注情况。主要结局为住院期间及24个月时的全因死亡。
13422例患者（70.2%）出现大汗，这与年龄<65岁、严重胸痛、当前吸烟状态及入院时心率<100次/分相关。大汗组更可能接受直接PCI（44.7%对32.9%），但PCI术后TIMI 3级血流（95.5%对94.1%）和STR≥50%（79.8%对78.2%）的发生率相似。多变量分析后，大汗与较低的住院死亡率（5.9%对8.6%，比值比[OR]：0.81，95%置信区间[CI]：0.72 - 0.92）及24个月死亡率（11.0%对17.2%）相关，风险比[HR]：0.75，95% CI：0.69 - 0.82）。即使在接受直接PCI且心肌再灌注成功的患者中也是如此，这种短期（2.5%对4.2%，OR：0.60，95% CI：0.45 - 0.80）和长期（5.9%对8.7%，HR：0.68，95% CI：0.56 - 0.83）的预后意义依然显著。
对于STEMI患者，无论直接PCI是否成功，大汗与较低死亡率相关，这突出了基于出汗表现进行早期风险分层的潜力。
https//www.
gov。唯一标识符：NCT01874691。2013年6月11日注册。
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