在诊断性操作前通过用无菌盐水冲洗工作通道降低支气管镜检查后肺炎的发生率。
Reduction of post-bronchoscopy pneumonia by working channel irrigation with sterile saline before diagnostic procedures.
作者信息
Nagaoka Satoshi, Yamamoto Masaki, Takakura Sachi, Okazaki Shunsuke, Nakadegawa Ryo, Suzukawa Yuichiro, Tanaka Anna, Matsushita Shinya, Muraoka Tatsuya, Maeda Chihiro, Hirose Tomofumi, Seki Kenichi, Teranishi Shuhei, Tashiro Ken, Kudo Makoto, Kaneko Takeshi
机构信息
Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, 236-0004, Japan.
Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune, Minami-Ku, Yokohama, 232-0024, Japan.
出版信息
BMC Pulm Med. 2025 May 20;25(1):243. doi: 10.1186/s12890-025-03726-6.
BACKGROUND
After transbronchial biopsy with flexible bronchoscopy, pneumonia sometimes occurs as a complication. The goal of our study was to determine whether irrigation of the working channel before diagnostic procedures can reduce the frequency of post-bronchoscopy pneumonia.
METHODS
Initially, we examined the effect of working channel irrigation with 100 mL of sterile saline to reduce the number of bacteria attached to the working channel. Subsequently, we compared the frequency of post-bronchoscopy pneumonia in patients who underwent or did not undergo working channel irrigation before bronchoscopic biopsy or lavage fluid collection.
RESULTS
THE MAIN FINDINGS: A significant reduction in bacterial colonies was observed in the irrigated channel-flush samples. Of the 242 enrolled participants, 109 were in the exploratory group, whereas 133 were in the control group. The frequency of post-bronchoscopy pneumonia (PBP) was 2.8% (n = 3) and 3.8% (n = 5) in the exploratory and control groups, respectively.
CONCLUSIONS
While the irrigation by suctioning 100 mL of sterile saline was effective in reducing the bacterial load within the channel, the reduction in pneumonia incidence did not reach statistical significance, indicating the need for further accumulation of cases.
背景
在使用可弯曲支气管镜进行经支气管活检后，肺炎有时会作为一种并发症出现。我们研究的目的是确定在诊断性操作前对操作通道进行冲洗是否可以降低支气管镜检查后肺炎的发生率。
方法
首先，我们检查了用100毫升无菌盐水冲洗操作通道对减少附着在操作通道上的细菌数量的效果。随后，我们比较了在支气管镜活检或灌洗液体采集前接受或未接受操作通道冲洗的患者中支气管镜检查后肺炎的发生率。
结果
主要发现：在冲洗后的通道冲洗样本中观察到细菌菌落显著减少。在242名登记参与者中，109名在探索组，而133名在对照组。探索组和对照组的支气管镜检查后肺炎（PBP）发生率分别为2.8%（n = 3）和3.8%（n = 5）。
结论
虽然通过抽吸100毫升无菌盐水进行冲洗有效地减少了通道内的细菌负荷，但肺炎发生率的降低未达到统计学意义，表明需要进一步积累病例。
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