Hewavitharana Jayani, Steinhofel Kathleen, Giese Karl Peter, Ierardi Carolina Moretti, Anand Amida
Department of Informatics, King's College London, London, United Kingdom.
Department of Basic and Clinical Neuroscience, King's College London, London, United Kingdom.
Front Comput Neurosci. 2025 May 6;19:1565660. doi: 10.3389/fncom.2025.1565660. eCollection 2025.
Learning and memory are fundamental processes of the brain which are essential for acquiring and storing information. However, with ageing the brain undergoes significant changes leading to age-related cognitive decline. Although there are numerous studies on computational models and approaches which aim to mimic the learning process of the brain, they often concentrate on generic neural function exhibiting the potential need for models that address age-related changes in learning. In this paper, we present a computational analysis focusing on the differences in learning between young and old brains. Using a bipartite graph as an artificial neural network to model the synaptic connections, we simulate the learning processes of young and older brains by applying distinct biologically inspired synaptic weight update rules. Our results demonstrate the quicker learning ability of young brains compared to older ones, consistent with biological observations. Our model effectively mimics the fundamental mechanisms of the brain related to the speed of learning and reveals key insights on memory consolidation.
学习和记忆是大脑的基本过程,对于获取和存储信息至关重要。然而,随着年龄的增长,大脑会发生显著变化,导致与年龄相关的认知能力下降。尽管有许多关于旨在模拟大脑学习过程的计算模型和方法的研究,但它们通常专注于一般的神经功能,这表明可能需要能够解决与年龄相关的学习变化的模型。在本文中,我们进行了一项计算分析,重点关注年轻大脑和老年大脑在学习方面的差异。我们使用二分图作为人工神经网络来模拟突触连接,通过应用不同的受生物学启发的突触权重更新规则,模拟年轻大脑和老年大脑的学习过程。我们的结果表明,与老年大脑相比,年轻大脑的学习能力更快,这与生物学观察结果一致。我们的模型有效地模拟了与学习速度相关的大脑基本机制,并揭示了关于记忆巩固的关键见解。