Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Semin Cell Dev Biol. 2022 May;125:84-90. doi: 10.1016/j.semcdb.2021.05.015. Epub 2021 May 19.
Synapses are specialized sites where neurons connect and communicate with each other. Activity-dependent modification of synaptic structure and function provides a mechanism for learning and memory. The advent of high-resolution time-lapse imaging in conjunction with fluorescent biosensors and actuators enables researchers to monitor and manipulate the structure and function of synapses both in vitro and in vivo. This review focuses on recent imaging studies on the synaptic modification underlying learning and memory.
突触是神经元相互连接和通讯的特化部位。突触结构和功能的活性依赖性修饰为学习和记忆提供了一种机制。高分辨率延时成像技术与荧光生物传感器和执行器的结合，使研究人员能够在体外和体内监测和操纵突触的结构和功能。本综述重点介绍了学习和记忆相关的突触修饰的最新成像研究。
