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姜黄素:一种潜在的抗光老化剂。

Curcumin: a potential anti-photoaging agent.

作者信息

Nie Yuhong, Li Yiming

机构信息

Department of Dermatology, Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.

出版信息

Front Pharmacol. 2025 May 6;16:1559032. doi: 10.3389/fphar.2025.1559032. eCollection 2025.

Abstract

Turmeric, also referred to as , is a commonly used spice, recognized for its demonstrated effects in reducing inflammation, combating microbes, providing antioxidant benefits, slowing the aging process, and exhibiting anticancer potential. The process of skin aging is intricate, with ultraviolet radiation being a significant extrinsic factor. Increasing evidence suggests that curcumin, the active component of turmeric, can prevent ultraviolet radiation-induced skin photoaging and related inflammation. Its effects include inhibition of melanin production, wrinkle reduction, antioxidant and anti-inflammatory actions. This review primarily focuses on the specific signaling pathways involved in skin photoaging and the mechanisms by which curcumin mitigates photoaging. Key topics include the antioxidant and anti-inflammatory properties of curcumin, regulation of matrix metalloproteinase, regulation of autophagy and apoptosis, improvement of pigmentation, and regulation of microbial balance. Additionally, addressing the critical issue of curcumin's low bioavailability, the review summarizes the latest advancements in curcumin formulation improvements. This article aims to provide a comprehensive overview of curcumin's progress of skin photoaging research and offer evidence for its further clinical application in dermatological treatments. The review contributes to a deeper understanding of the potential molecular mechanisms of curcumin in combating photoaging and presents new insights for the development of curcumin-based anti-photoaging products.

摘要

姜黄,也被称为 ,是一种常用香料,因其在减轻炎症、对抗微生物、提供抗氧化益处、延缓衰老过程以及展现抗癌潜力等方面的显著效果而闻名。皮肤衰老过程错综复杂,紫外线辐射是一个重要的外在因素。越来越多的证据表明,姜黄的活性成分姜黄素可以预防紫外线辐射引起的皮肤光老化及相关炎症。其作用包括抑制黑色素生成、减少皱纹、抗氧化和抗炎作用。本综述主要关注皮肤光老化所涉及的特定信号通路以及姜黄素减轻光老化的机制。关键主题包括姜黄素的抗氧化和抗炎特性、基质金属蛋白酶的调节、自噬和凋亡的调节、色素沉着的改善以及微生物平衡的调节。此外,针对姜黄素生物利用度低这一关键问题,综述总结了姜黄素制剂改进方面的最新进展。本文旨在全面概述姜黄素在皮肤光老化研究方面的进展,并为其在皮肤科治疗中的进一步临床应用提供证据。该综述有助于更深入地理解姜黄素对抗光老化的潜在分子机制,并为基于姜黄素的抗光老化产品的开发提供新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c93/12090238/b95075b854d3/fphar-16-1559032-g001.jpg

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